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PF 06260933 dihydrochloride

Catalog #: 5752
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5752/10
5752/50
PF 06260933 dihydrochloride | CAS No. 1883548-86-4 | HGK
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Description: MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

Chemical Name: 5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Technical Data

M.Wt:
369.68
Formula:
C16H13ClN4.2HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1883548-86-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data
    BL Strang, CRM Asquith, HF Moshrif, CM Ho, WJ Zuercher, H Al-Ali
    PLoS ONE, 2018;13(7):e0201321.
  2. Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment.
    Ammirati et al.
    ACS Med.Chem.Lett., 2015;6:1128

Product Datasheets

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Citations for PF 06260933 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PF 06260933 dihydrochloride include:

2 Citations: Showing 1 - 2

  1. Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.
    Authors: Sebastian Et al.
    Cell Chem Biol  2019;26:1703-1715.e37
  2. MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.
    Authors: Gao Et al.
    Mol Oncol  2017;11:628

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