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PF 06465469

Catalog #: 4710
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4710/10
4710/50
PF 06465469 | CAS No. 1407966-77-1 | ITK Inhibitors
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Description: Potent ITK inhibitor; also inhibits BTK

Chemical Name: (R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 06465469 is a potent inhibitor of interleukin-2 inducible T cell kinase (ITK) (IC50 = 2 nM). Also exhibits inhibitory activity against Bruton's tyrosine kinase (BTK) (IC50 = 2 nM). Displays nanomolar potencies in a cell-based IP1 assay and human whole blood assay (IC50 values are 31 and 48 nM respectively).

Technical Data

M.Wt:
523.63
Formula:
C30H33N7O2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
1407966-77-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 06465469

The citations listed below are publications that use Tocris products. Selected citations for PF 06465469 include:

2 Citations: Showing 1 - 2

  1. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL.
    Authors: Christopher J Et al.
    Cancer Res  2022;82:3375-3393
  2. Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma.
    Authors: Mamand Et al.
    Sci Rep  2018;8:14216

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