PF 3644022

Key Product Details

Product Description

PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC₅₀ = 5.2 nM; K_i = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC₅₀ = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3644022 is reviewed on the chemical probes website..

Product Specifications for PF 3644022

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PF 3644022

The following data is based on the product molecular weight 374.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.4 mM	6.68 mL	33.38 mL	66.76 mL
2 mM	1.34 mL	6.68 mL	13.35 mL
4 mM	0.67 mL	3.34 mL	6.68 mL
20 mM	0.13 mL	0.67 mL	1.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 49 publications citing the usage of this product.

• Mourey A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J.Pharmacol.Exp.Ther. 2010 PMID: 20237073

Product Documents for PF 3644022