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Phototrexate

Catalog #: 7362 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7362/5
Phototrexate | CAS No. 2268033-83-4 | Dihydrofolate Reductase Inhibitors
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Description: Photoswitchable inhibitor of human dihydrofolate reductase

Chemical Name: N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid

Purity: ≥95%

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Biological Activity

Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate (Cat. No. 1230). Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark. cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared with trans-Phototrexate (IC50 = 34 μM).

Scientific Data

N/A Photoswitching activity of Phototrexate View Larger

Photoswitching activity of Phototrexate Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.

Technical Data

M.Wt:
437.42
Formula:
C20H19N7O5
Solubility:
Soluble to 4 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2268033-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with permission of IBEC.

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