Pindolol
Discontinued Product
Chemical Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity: ≥99%
Biological Activity
5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors.S-enantiomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor.
Blin et al.
Mol.Pharmacol., 1993;44:1094 -
Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain.
Corradetti et al.
Br.J.Pharmacol., 1998;123:449 -
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Pharmacol.Rev., 1994;46:157 -
Electrophysiological and neurochemical evidence that pin. has agonist properties at the 5-HT1A autoreceptor in vivo.
Clifford et al.
Br.J.Pharmacol., 1998;124:206
Product Datasheets
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Citations for Pindolol
The citations listed below are publications that use Tocris products. Selected citations for Pindolol include:
5 Citations: Showing 1 - 5
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β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro.
Authors: Luo
Scientific Reports 2017;7:39905
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Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
Authors: Littmann Et al.
Front Microbiol 2015;355:183
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Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion.
Authors: Zaytseva Et al.
Sens Actuators B Chem 2013;188
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Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation.
Authors: Kleinbongard Et al.
Circ Res 2011;108:344
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Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous.
Authors: Marinelli Et al.
J Neurophysiol 2004;92:3532
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