Pitavastatin calcium
Chemical Name: (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt
Purity: ≥99%
Biological Activity
Pitavastatin calcium is a synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure.
Saka et al.
J.Cardiovasc.Pharmacol., 2006;47:770 -
Pitavastatin.
Mukhtar et al.
Int.J.Clin.Pract., 2005;59:239 -
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Aoki et al.
Arzneimittelforschung., 1997;47:904
Product Datasheets
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Citation for Pitavastatin calcium
The citations listed below are publications that use Tocris products. Selected citations for Pitavastatin calcium include:
1 Citation: Showing 1 - 1
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Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects.
Authors: Laurent Et al.
Cancers (Basel) 2021;13
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