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PK 44 phosphate

Catalog #: 4145 Datasheet / COA / SDS

Discontinued Product

4145 has been discontinued.
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PK 44 phosphate | CAS No. 1017682-66-4 | DPPIV/CD26 Inhibitors
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Description: Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor

Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate

Purity: ≥98%

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Biological Activity

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Technical Data

M.Wt:
527.34
Formula:
C17H16F5N7O.H3PO4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1017682-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes.
    Tozer et al.
    32nd Annual National Medicinal Chemistry Symposium, 2010;:Poster 52

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