PKI 14-22 amide, myristoylated

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.
   Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, Mizokami A, Tanaka H, Irifune M, Kamata N, Hirata M, Kanematsu T
   PLoS ONE, 2014;9(6):e100559.
2. Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro.
   Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD
   Endocrinology, 2012;153(5):2208-22.
3. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
   Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, Muller W
   J Exp Med, 2015;212(7):1021-41.
4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
   Wang C, Held R, Hall B
   PLoS ONE, 2013;8(12):e83941.
5. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
   Singh J, Wen X, Scales S
   J Biol Chem, 2015;290(49):29663-75.
6. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein.
   Glass et al.
   J.Biol.Chem., 1989;264:8802
7. Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1.
   Zheng et al.
   J.Biol.Chem., 2000;275:31747
8. Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A.
   Farrow et al.
   Surgery, 2003;134:197

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