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PNU 22394 hydrochloride

Catalog #: 2201 Datasheet / COA / SDS

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2201 has been discontinued.
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PNU 22394 hydrochloride | CAS No. 15923-42-9 | 5-HT2C Receptor Agonists
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Description: 5-HT2C agonist and 5-HT2A/2B partial agonist

Chemical Name: 1,2,3,4,5,6-Hexahydro-6-methyl-azepino[4,5-b]indole hydrochloride

Purity: ≥99%

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Biological Activity

PNU 22394 hydrochloride is a potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.

Technical Data

M.Wt:
236.74
Formula:
C13H16N2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
15923-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Serotonin is a key factor for mouse red blood cell survival.
    Amireault P, Bayard E, Launay J, Sibon D, Le Van Kim C, Colin Y, Dy M, Hermine O, Cote F
    PLoS ONE, 2013;8(12):e83010.
  2. PNU-22394, a 5-HT2C receptor agonist, reduces feeding in rodents and produces weight loss in humans.
    McCall et al.
    Soc.Neurosci.Abstr., 2001;27:309
  3. Design, synthesis and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
    Jensen et al.
    J.Med.Chem., 2013;56:1211

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