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Pomalidomide 4'-PEG2-amine

Catalog #: 6637 1 Review Datasheet / COA / SDS
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6637/25
Pomalidomide 4'-PEG2-amine | CAS No. 2245697-87-2 | Degrader Building Blocks
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Description: Cereblon ligand with PEG linker and terminal amine for onward chemistry
Alternative Names: Pomalidomide - linker 1

Chemical Name: 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

Purity: ≥95%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pomalidomide 4'-PEG2-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Pomalidomide - linker 1

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
440.88
Formula:
C19H24N4O6.HCl
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2245697-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Degradation of the BAF complex factor BRD9 by heterobifunctional ligands.
    Remillard et al.
    Angew.Chem.Int.Ed.Engl., 2017;56:5738

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Targeted protein degradation
By Sandipan Roy Chowdhury on 05/20/2020
Species: cells

to make protacs

Targeted protein degradation 6637
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.