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Pravastatin sodium salt

Catalog #: 2318
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2318/50
Pravastatin sodium salt | CAS No. 81131-70-6 | HMG-CoA Reductase Inhibitors
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Description: HMG-CoA reductase inhibitor
Alternative Names: Eptastatin sodium

Chemical Name: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pravastatin sodium salt is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.

Technical Data

M.Wt:
446.51
Formula:
C23H35NaO7
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
81131-70-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Pravastatin sodium, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Pravastatin sodium salt

The citations listed below are publications that use Tocris products. Selected citations for Pravastatin sodium salt include:

3 Citations: Showing 1 - 3

  1. AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability.
    Authors: Ding Et al.
    Circ Res  2016;119:718
  2. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
    Authors: Rojo-Arreola Et al.
    PLoS One  2014;9:e87594
  3. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT.
    Authors: Vainio Et al.
    Proc Natl Acad Sci U S A  2011;2:1176

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