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ProINDY

Catalog #: 4998
2 Citations Datasheet / COA / SDS

Discontinued Product

4998 has been discontinued.
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ProINDY | CAS No. 719277-30-2 | DYRK Inhibitors
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Description: DYRK1A/B inhibitor; prodrug of INDY (Cat. No. 4997)

Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ProINDY is a DYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.

Technical Data

M.Wt:
277.34
Formula:
C14H15NO3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
719277-30-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ProINDY

The citations listed below are publications that use Tocris products. Selected citations for ProINDY include:

2 Citations: Showing 1 - 2

  1. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
    Authors: Kim Et al.
    Dis Model Mech  2016;9:839
  2. Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.
    Authors: Seu Et al.
    Sci Rep  2015;89:6656

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