ProTx II

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Structural basis of Na_v1.7 inhibition by a gating-modifier spider toxin.
   Xu et al.
   Cell., 2019;
2. Molecular interactions of the gating modifier toxin ProTx-II with Na_V 1.5: implied existence of a novel toxin binding site coupled to activation.
   Smith et al.
   J.Biol.Chem., 2007;282:12687
3. Evidence for multiple effects of ProTxII on activation gating in Na_V 1.5.
   Edgerton et al.
   Toxicon., 2008;52:489
4. ProTx-II, a selective inhibitor of Na_V 1.7 sodium channels, blocks action potential propagation in nociceptors.
   Schmalhofer et al.
   Mol.Pharmacol., 2008;74:1476

Product Datasheets