Psalmotoxin 1
Purity: ≥95%
Biological Activity
Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker (IC50 = 0.9 nM). Displays no effect at ASIC1b, ASIC2a, ASIC3, heteromeric ASIC channels, ENaC and KV2.1/2.2/4.2/4.3 channels expressed in oocytes, at concentrations up to 100 nM. Displays potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents.Technical Data
(Modifications: Disulfide bridges: 3-18, 10-23, 17-33)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.
Escoubas et al.
Protein Sci., 2003;12:1332 -
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
Escoubas et al.
J.Biol.Chem., 2000;275:25116 -
A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.
Mazzuca et al.
Nat.Neurosci., 2007;10:943 -
The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.
Salinas et al.
J.Physiol., 2006;570:339
Product Datasheets
Reconstitution Calculator
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Citations for Psalmotoxin 1
The citations listed below are publications that use Tocris products. Selected citations for Psalmotoxin 1 include:
2 Citations: Showing 1 - 2
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Regulation of gliomagenesis and stemness through acid sensor ASIC1a.
Authors: Shanchun Et al.
Int J Oncol 2021;59
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ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain.
Authors: Chih-Cheng Et al.
Elife 2021;10
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