PSB 0788
Chemical Name: 8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity: ≥98%
Biological Activity
PSB 0788 is a potent and selective adenosine A2B receptor antagonist (IC50 = 3.64 nM at human A2B receptors). Displays > 100-fold selectivity over hA1, hA2A and hA3 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages.
Koscso B, Csoka B, Kokai E, Nemeth Z, Pacher P, Virag L, Leibovich S, Hasko G
J Leukoc Biol, 2013;94(6):1309-15. -
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
Borrmann et al.
J.Med.Chem., 2009;52:3994
Product Datasheets
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Citations for PSB 0788
The citations listed below are publications that use Tocris products. Selected citations for PSB 0788 include:
2 Citations: Showing 1 - 2
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Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer.
Authors: Al-Taei Et al.
Oncoimmunology 2017;6:e1268308
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An Adenosine Receptor for Olfaction in Fish.
Authors: Wakisaka Et al.
Curr Biol 2017;27:1437
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