Home / Adenosine A2b Receptor Antagonists / PSB 603

PSB 603

Catalog #: 3198
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3198/10
3198/50
PSB 603 | CAS No. 1092351-10-4 | Adenosine A2b Receptor Antagonists
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Description: Highly selective A2B antagonist

Chemical Name: 8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine

Purity: ≥98%

Product Details
Citations (6)
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Biological Activity

PSB 603 is an adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively). Downregulates the expression of osteocalcin and osteopontin during osteogenic differentiation of mesenchymal stem cells.

Technical Data

M.Wt:
529.01
Formula:
C24H25ClN6O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1092351-10-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PSB 603

The citations listed below are publications that use Tocris products. Selected citations for PSB 603 include:

6 Citations: Showing 1 - 6

  1. Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.
    Authors: Kang Et al.
    Sci Adv  2016;2:e1600691
  2. Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices.
    Authors: Rao Et al.
    Front Bioeng Biotechnol  2015;3:185
  3. p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death.
    Authors: Long Et al.
    J Pharmacol Exp Ther  2015;34:5152
  4. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
    Authors: Schneider Et al.
    Oncogene  2015;14:201
  5. Application of BRET to monitor ligand binding to GPCRs.
    Authors: Stoddart Et al.
    Nat Methods  2015;12:661
  6. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats.
    Authors: Ham Et al.
    Proc Natl Acad Sci U S A  2010;335:607

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