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Pyr3

Catalog #: 3751
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3751/10
3751/50
Pyr3 | CAS No. 1160514-60-2 | TRPC Channel Blockers
1 Image
Description: Selective TRPC3 inhibitor

Chemical Name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pyr3 is a selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

Technical Data

M.Wt:
456.63
Formula:
C16H11Cl3F3N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1160514-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.
    Kiyonaka et al.
    Proc.Natl.Acad.Sci., 2009;106:5400

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Citations for Pyr3

The citations listed below are publications that use Tocris products. Selected citations for Pyr3 include:

5 Citations: Showing 1 - 5

  1. Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle.
    Authors: Y S Et al.
    FASEB J  2020;34:12991-13004
  2. Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.
    Authors: Szteyn Et al.
    Am J Physiol Regul Integr Comp Physiol  2015;7
  3. Cerebellar modules operate at different frequencies.
    Authors: Zhou Et al.
    Elife  2014;3:e02536
  4. TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
    Authors: Lee Et al.
    J Neurosci  2013;33:1157
  5. Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
    Authors: Senadheera Et al.
    ACS Chem Neurosci  2013;305:R917

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