PZ-II-029
Chemical Name: 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
Purity: ≥98%
Biological Activity
PZ-II-029 is a GABAA positive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors.
Varagic et al.
Br.J.Pharmacol., 2013;169:384 -
The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation.
Fan et al.
Neuropharmacology., 2018;140:1
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