Quizartinib
Chemical Name: N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
Purity: ≥98%
Biological Activity
Quizartinib is a highly potent FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor (Kd = 1.6 nM, IC50 = 0.56 nM in MV4-11 cell proliferation assay). Displays >10-fold selectivity for FLT3 over panel of 400 kinases. Inhibits FLT3 activity and displays antitumor properties in a mouse MV4-11 tumor xenograft model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Zarrinkar et al.
Blood., 2009;114:2984 -
Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like ty
Chao et al.
J.Med.Chem., 2009;52:7808
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Citation for Quizartinib
The citations listed below are publications that use Tocris products. Selected citations for Quizartinib include:
1 Citation: Showing 1 - 1
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Combinatorial molecule screening identified a novel diterpene and the BET inhibitor CPI-203 as differentiation inducers of primary acute myeloid leukemia cells.
Authors: Thoas Et al.
Haematologica 2021;106:2566-2577
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