Home / Other Transferase Inhibitors / (R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt

Catalog #: 4539
16 Citations 1 Review Datasheet / COA / SDS
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4539/10
4539/50
(R)-(+)-Etomoxir sodium salt | CAS No. 828934-41-4 | Other Transferase Inhibitors
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Description: Carnitine palmitoyltransferase I (CPT1) inhibitor

Chemical Name: (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt

Purity: ≥98%

Product Details
Citations (16)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Technical Data

M.Wt:
320.74
Formula:
C15H18ClNaO4
Solubility:
Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
828934-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
    JC Schell, DR Wisidagama, C Bensard, H Zhao, P Wei, J Tanner, A Flores, J Mohlman, LK Sorensen, CS Earl, KA Olson, R Miao, TC Waller, D Delker, P Kanth, L Jiang, RJ DeBerardin, MP Bronner, DY Li, JE Cox, HR Christofk, WE Lowry, CS Thummel, J Rutter
    Nat. Cell Biol., 2017;19(9):1027-1036.
  2. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells.
    Xu et al.
    J.Lipid Res., 2003;44:415
  3. Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes.
    Agius et al.
    Biochem.Pharmacol., 1991;42:1717
  4. Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor.
    Rupp et al.
    FASEB J., 1992;6:2349
  5. Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.
    Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid
    The Journal of Experimental Medicine, 2016;0(0):1540-9538.
  6. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020;0(0):.

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Citations for (R)-(+)-Etomoxir sodium salt

The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-Etomoxir sodium salt include:

16 Citations: Showing 1 - 10

  1. Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysis.
    Authors: Elizabeth A Et al.
    STAR Protoc  2022;3:101389
  2. α1-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes.
    Authors: Robert S Et al.
    J Recept Signal Transduct Res  2021;41:138-144
  3. β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME.
    Authors: Scott I Et al.
    Cell Rep  2021;37:109883
  4. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
    Authors: Santosh Et al.
    Cell Rep  2021;34:108869
  5. Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
    Authors: Eduards Et al.
    Int J Mol Sci  2021;22
  6. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
    Authors: Jonas Thue Et al.
    Cell  2021;184:3502-3518.e33
  7. Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation.
    Authors: Navdeep S Et al.
    Front Physiol  2021;11:630910
  8. Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes.
    Authors: Roberta Et al.
    J Vis Exp  2021;
  9. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
    Authors: Ryan M Et al.
    Cell Rep  2020;30:2889-2899.e6
  10. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells.
    Authors: Carine Et al.
    Nat Commun  2020;11:454

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etomoxir was used as a CPT1 inhibitor
By Anonymous on 10/05/2018

Etomoxir was used as a CPT1 inhibitor in endothelial cells. The data was shown in the publication PubMed ID 29429925.

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