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(R)-ZINC 3573

Catalog #: 6351 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6351/5
6351/25
(R)-ZINC 3573 | CAS No. 2089389-15-9 | Mas-Related G Protein Coupled Receptor Agonists
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Description: MRGPRX2 agonist

Chemical Name: (3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

Purity: ≥98%

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Biological Activity

(R)-ZINC 3573 is a Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist (EC50 = 0.74 μM), which displays selectivity for MRGPRX2 over 350 other GPCRs, including MRGPRX1. (R)-ZINC 3573 induces intracellular calcium release and degranulation in LAD2 mast cells in vitro.

Negative control (S)-ZINC 3573 (Cat. No. 6352) also available.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of (R)-ZINC 3573 is reviewed on chemicalprobes.org and the SGC website.

Technical Data

M.Wt:
307.4
Formula:
C18H21N5
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2089389-15-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In silico design of novel probes for the atypical opioid receptor MRGPRX2.
    Lansu et al.
    Nat.Chem.Biol., 2017;13:529

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