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Rac1 Inhibitor W56

Catalog #: 2221
4 Citations Datasheet / COA / SDS

Discontinued Product

2221 has been discontinued.
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Rac1 Inhibitor W56
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Description: Selective inhibitor of Rac1-GEF interaction
Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Rac1 Inhibitor W56 is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.

Control Peptide also available.

Technical Data

M.Wt:
1671.93
Formula:
C74H117N19O23S
Sequence:
MVDGKPVNLGLWDTAG
Solubility:
Soluble to 2 mg/ml in PBS (pH 7.4)
Storage:
Desiccate at -20°C
CAS No:
1095179-01-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Trp56 of Rac1 specifies interaction with a subset of guanine nucleotide exchange factors.
    Gao et al.
    J.Biol.Chem., 2001;276:47530

Product Datasheets

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Citations for Rac1 Inhibitor W56

The citations listed below are publications that use Tocris products. Selected citations for Rac1 Inhibitor W56 include:

4 Citations: Showing 1 - 4

  1. Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.
    Authors: Bessa Et al.
    Cell Death Dis  2019;10:143
  2. Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against dox. in a biomimetic 3D lymphoma model.
    Authors: Ikram Et al.
    Oncotarget  2018;9:2058
  3. Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.
    Authors: Kruppa Et al.
    Dev Cell  2018;44:484
  4. SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.
    Authors: Zeineddine Et al.
    Am J Physiol Lung Cell Mol Physiol  2015;10:57

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