Reboxetine mesylate
Chemical Name: (2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate
Purity: ≥99%
Biological Activity
Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). Displays > 1000-fold selectivity over α-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain.
Sacchetti et al.
Br.J.Pharmacol., 1999;128:1332 -
Reboxetine: a pharmacologically potent, selective, and specific NE reuptake inhibitor.
Wong et al.
Biol.Psychiatry., 2000;47:818 -
S33005, a novel ligand at both serotonin and NE transporters: I Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.
Millan et al.
J.Pharmacol.Exp.Ther., 2001;298:565 -
Reboxetine modulates NE efflux in the frontal cortex of the freely moving rat: the involvement of α2 and 5-HT1A receptors.
Owen and Whitton
Neurosci.Lett., 2003;348:171
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Citations for Reboxetine mesylate
The citations listed below are publications that use Tocris products. Selected citations for Reboxetine mesylate include:
9 Citations: Showing 1 - 9
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Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.
Authors: Kreiner Et al.
Sci Rep 2019;9:5262
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Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice.
Authors: Zhu Et al.
Bone Rep 2018;9:188
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Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects.
Authors: Munari Et al.
Neurochem Int 2015;18:pyv045
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Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Authors: Suto Et al.
Pain 2014;155:1935
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A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
Neuropsychopharmacology 2013;38:1625
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Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
Authors: Hughes Et al.
Int J Neuropsychopharmacol 2013;154:1680
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Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
Authors: Ferreira Et al.
Theriogenology 2012;61:219
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Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
Authors: Hutchinson Et al.
Pain 2012;37:321
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Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective NE reuptake inhibitors atomox. and reboxetine.
Authors: Kobayashi Et al.
Neuropsychopharmacology 2010;35:1560
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