Home / HB-EGF / Recombinant Human HB-EGF Protein

Recombinant Human HB-EGF Protein

Catalog #: 259-HE
68 Citations 1 Review Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
259-HE-050/CF
259-HE-250/CF

With Carrier

Catalog # Availability Size / Price Qty
259-HE-050
259-HE-250
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Citations (68)
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Reviews (1)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human HB-EGF Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE with silver staining
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. Rubin, J.S. et al. (1991) Proc. Natl. Acad. Sci. USA 88:415. The ED50 for this effect is 0.15-0.75 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human HB-EGF protein
Asp63-Leu148
Accession #
Q99075
N-terminal Sequence
Analysis
Asp63 (major), Gly32, Glu24
Predicted Molecular Mass
9.7 kDa
SDS-PAGE
11-20 kDa, reducing conditions

Product Datasheets

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259-HE (with carrier)

Product Datasheet
COA
SDS

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259-HE/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

259-HE

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 250 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

259-HE/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: HB-EGF

Human HB-EGF (Heparin-Binding EGF-like growth factor) is a 12-16 kDa member of the EGF family of peptide growth factors (1-3). Also known as the DTR (diphtheria toxin receptor), it is further classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors (4, 5). HB-EGF is synthesized as a 208 amino acid (aa) type I transmembrane preproprecursor (1, 6). It contains a 19 aa signal sequence, a 43 aa prosegment, an 86 aa mature region (aa 63-148), an 11 aa juxtamembrane cleavage peptide, a 24 aa transmembrane segment, and a 25 aa cytoplasmic tail (aa 184-208). As an integral membrane protein, HB-EGF is expressed as a 19-27 kDa protein in mammalian cells (7-9). The variability in molecular weight (MW) is attributed to heterogeneity in glycosylation and/or the utilization of multiple proteolytic cleavage sites during maturation. Mature HB-EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. It possesses an EGF-like domain between aa 104-144, and a heparin-binding motif between aa 93‑113. Although the aa range for "mature" HB-EGF is typically stated to be Asp63-Leu148, potential N-terminal start (cleavage) sites also exist at Gly32, Arg73, Val74, Ser77 and Ala82 (8, 10-12). Thus, differential processing (in part) likely accounts for the 16-23 kDa range in MW noted for mammalian-derived mature HB-EGF. Proteases suggested to contribute to HB-EGF processing include TACE, MMP-3 and -7, ADAM-17 and ADAM-12 (11, 13-16). When expressed recombinantly in E.coli, HB-EGF (aa 73-148) runs at 14 kDa in SDS-PAGE; when expressed in Baculovirus, HB-EGF (aa 63-148, 77-148 and 32-148) runs at 18 kDa, 15 kDa, and 19 kDa respectively (8, 12, 17). Over aa 63-148, human HB-EGF- shares 76% and 73% aa sequence identity with rat and mouse HB-EGF, respectively (1, 18). Cells known to express HB-EGF include bronchial epithelium (19), visceral and vascular smooth muscle (20, 21), CD4+ T cells (22), cardiac muscle (23), glomerular podocytes (24), keratinocytes (13) and IL-10-secreting regulatory macrophages (25). As noted earlier, HB-EGF is known to bind to both 170 kDa EGFR and 180 kDa ErbB4, and through heterodimerization, ErbB2 (13, 26). Activity associated with ErbB4 binding appears to be limited to non-mitogenic actions, while EGFR binding induces both mitogenic and non-mitogenic activity.

References
  1. Higashiyama, S et al. (1991) Science 251:936.
  2. Schneider, MR & E. Wolf (2009) J. Cell. Physiol. 218:460.
  3. G.V. Sherbet (2011) The Epidermal Growth Factor (EGF) Family in Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy, Pages 173-198. Elsevier, NY.
  4. Iwamoto, R & E. Mekada (2000) Cytokine Growth Factor Rev. 11:335.
  5. Miyata, K. et al. (2012) Anticancer Res. 32:2347.
  6. SwissProt:Q99075.
  7. Raab, G. et al. (1994) Biochem. Biophys. Res. Commun. 204:592.
  8. Nakagawa, T. et al. (1996) J. Biol. Chem. 271:30858.
  9. Higashiyama, S. et al. (1995) J. Cell Biol. 128:929.
  10. Higashiyama, S. et al. (1992) J. Biol. Chem. 267:6205.
  11. Hinkle, C.L. et al. (2004) J. Biol. Chem. 279:24179.
  12. Ono, M. et al. (1994) J. Biol. Chem. 269:31315.
  13. Nanba, D. & S. Higashiyama (2004) Cytokine Growth Factor Rev. 15:13.
  14. Cheng, K. et al. (2007) Biochem. Pharmacol. 73:1001.
  15. Suzuki, M. et al. (1997) J. Biol. Chem. 272:31730.
  16. Asakura, M. et al. (2002) Nat. Med. 8:35.
  17. Marikovsky, M. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3889.
  18. Abraham, J.A. et al. (1993) Biochem. Biophys. Res. Commun. 190:125.
  19. Tschumperlin, D.J. et al. (2004) Nature 429:83.
  20. Park, J.M. et al. (1998) Am. J. Physiol. 275:C1247.
  21. Miyagawa, J. et al. (1995) J. Clin. Invest. 95:404.
  22. Blotnick, S. et al. (1994) Proc. Natl. Acad. Sci. USA 91:2890.
  23. Iwamoto, R. et al. (2003) Proc. Natl. Acad. Sci. USA 100:3221.
  24. Bollee, G. et al. (2011) Nat. Med. 17:1242.
  25. Edwards, J.P. et al. (2009) J. Immunol. 182:1929.
  26. Elenius, K. et al. (1997) EMBO J. 16:1268.
Long Name
Heparin Binding EGF-like Growth Factor
Entrez Gene IDs
1839 (Human); 15200 (Mouse)
Alternate Names
diphtheria toxin receptor (heparin-binding epidermal growth factor-like growthfactor); Dtr; DTRHEGFLdiphtheria toxin receptor (heparin-binding EGF-like growth factor); Dts; DTSF; HBEGF; HB-EGF; Hegfl; heparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; proheparin-binding EGF-like growth factor

Citations for Recombinant Human HB-EGF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

68 Citations: Showing 1 - 10
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  1. Uncovering a Novel Functional Interaction Between Adult Hepatic Progenitor Cells, Inflammation and EGFR Signaling During Bile Acids-Induced Injury
    Authors: García-Sáez, J;Figueroa-Fuentes, M;González-Corralejo, C;Roncero, C;Lazcanoiturburu, N;Gutiérrez-Uzquiza, Á;Vaquero, J;González-Sánchez, E;Bhutia, K;Calero-Pérez, S;Maina, F;Traba, J;Valverde, ÁM;Fabregat, I;Herrera, B;Sánchez, A;
    International journal of biological sciences
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Unique structural characteristics and biological activities of heparan sulfate isolated from the mantle of the scallop Chlamys farreri
    Authors: Qin, Y;Xu, Y;Yi, H;Shi, L;Wang, X;Wang, W;Li, F;
    Carbohydrate polymers
    Species: N/A
    Sample Types: Carbohydrates
    Applications: Surface Plasmon Resonance
  3. Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer
    Authors: Cigliola, V;Shoffner, A;Lee, N;Ou, J;Gonzalez, TJ;Hoque, J;Becker, CJ;Han, Y;Shen, G;Faw, TD;Abd-El-Barr, MM;Varghese, S;Asokan, A;Poss, KD;
    Nature communications
    Species: Zebrafish
    Sample Types: In Vivo
    Applications: In Vivo
  4. Spray-dried microparticles of encapsulated gefitinib for slow-release localized treatment of periodontal disease
    Authors: Baldelli, A;Koivisto, L;Oguzlu, H;Guo, Y;Häkkinen, L;Pratap-Singh, A;Larjava, H;
    International journal of pharmaceutics
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Pervasive environmental chemicals impair oligodendrocyte development
    Authors: EF Cohn, BLL Clayton, M Madhavan, S Yacoub, Y Federov, K Paul-Fried, TJ Shafer, PJ Tesar
    bioRxiv : the preprint server for biology, 2023-02-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. ADAM17-mediated EGFR ligand shedding directs macrophage promoted cancer cell invasion
    Authors: S Gnosa, L Puig-Blasc, KB Piotrowski, ML Freiberg, S Savickas, DH Madsen, U Auf dem Ke, P Kronqvist, M Kveiborg
    JCI Insight, 2022-09-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  7. Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
    Authors: ALM Caldwell, L Sancho, J Deng, A Bosworth, A Miglietta, JK Diedrich, MN Shokhirev, NJ Allen
    Nature Neuroscience, 2022-08-30;25(9):1163-1178.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
    Authors: Y Tang, DJ Kwiatkowsk, EP Henske
    Nature Communications, 2022-08-26;13(1):5018.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay
    Authors: S Martin, KC Allan, O Pinkard, T Sweet, PJ Tesar, J Coller
    Nature Communications, 2022-08-25;13(1):5003.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. EGFR ligand shifts the role of EGFR from oncogene to tumour suppressor in EGFR-amplified glioblastoma by suppressing invasion through BIN3 upregulation
    Authors: G Guo, K Gong, N Beckley, Y Zhang, X Yang, R Chkheidze, KJ Hatanpaa, T Garzon-Muv, P Koduru, A Nayab, J Jenks, AA Sathe, Y Liu, C Xing, SY Wu, CM Chiang, B Mukherjee, S Burma, B Wohlfeld, T Patel, B Mickey, K Abdullah, M Youssef, E Pan, DE Gerber, S Tian, JN Sarkaria, SK McBrayer, D Zhao, AA Habib
    Nature Cell Biology, 2022-08-01;24(8):1291-1305.
    Species: Human
    Sample Types:
  11. Kir4.2 Potassium Channels in Retinal Pigment Epithelial Cells In Vitro: Contribution to Cell Viability and Proliferation, and Down-Regulation by Vascular Endothelial Growth Factor
    Authors: MC Beer, H Kuhrt, L Kohen, P Wiedemann, A Bringmann, M Hollborn
    Biomolecules, 2022-06-18;12(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation
    Authors: G Parkinson, P Roboti, L Zhang, S Taylor, P Woodman
    Journal of Cell Science, 2021-11-04;134(21):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. A simple detection method for the serum sFLT1 protein in preeclampsia
    Authors: M Shibuya, H Matsui, T Sasagawa, T Nagamatsu
    Scientific Reports, 2021-10-18;11(1):20613.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Standard
  14. TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway
    Authors: HF Yu, LW Zheng, ZQ Yang, YS Wang, TT Wang, ZP Yue, B Guo
    Experimental & Molecular Medicine, 2021-09-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Synergistic induction of IL-23 by TNF&alpha, IL-17A, and EGF in keratinocytes
    Authors: B Ehst, Z Wang, J Leitenberg, D McClanahan, R De La Torr, E Sawka, AG Ortega-Loa, J Strunck, T Greiling, E Simpson, Y Liu
    Cytokine, 2020-11-02;0(0):155357.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
    Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
    Cell Stem Cell, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. NRF2 Knockdown Resensitizes 5-Fluorouracil-Resistant Pancreatic Cancer Cells by Suppressing HO-1 and ABCG2 Expression
    Authors: EJ Kim, YJ Kim, HI Lee, SH Jeong, HJ Nam, JH Cho
    Int J Mol Sci, 2020-06-30;21(13):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  18. M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB?EGF
    Authors: E Fu, T Liu, S Yu, X Chen, L Song, H Lou, F Ma, S Zhang, S Hussain, J Guo, J Sun, P Yu, X Mao, L Wei
    Oncol. Rep., 2020-05-29;44(2):698-710.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  19. HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage
    Authors: HF Yu, CC Duan, ZQ Yang, YS Wang, ZP Yue, B Guo
    Oxid Med Cell Longev, 2019-12-02;2019(0):6170936.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Cell Culture
  20. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
    Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
    Mol. Vis., 2019-06-30;25(0):329-344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Linking YAP to M�ller Glia Quiescence Exit in the Degenerative Retina
    Authors: A Hamon, D García-Gar, D Ail, J Bitard, A Chesneau, D Dalkara, M Locker, JE Roger, M Perron
    Cell Rep, 2019-05-07;27(6):1712-1725.e6.
    Species: Mouse
    Sample Types: In Vivo, Tissue Explant
    Applications: Bioassay, In Vivo
  22. NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells
    Authors: J Tchieu, EL Calder, SR Guttikonda, EM Gutzwiller, KA Aromolaran, JA Steinbeck, PA Goldstein, L Studer
    Nat. Biotechnol., 2019-02-25;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau
    Authors: MB Huynh, MO Ouidja, S Chantepie, G Carpentier, A Maïza, G Zhang, J Vilares, R Raisman-Vo, D Papy-Garci
    PLoS ONE, 2019-01-04;14(1):e0209573.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  24. Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis
    Authors: A Farinazzo, S Angiari, E Turano, E Bistaffa, S Dusi, S Ruggieri, R Bonafede, R Mariotti, G Constantin, B Bonetti
    Sci Rep, 2018-05-10;8(1):7473.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition
    Authors: T Lai, Y Li, M Chen, G Pan, X Wen, Z Mai, Y Yuan, Y Lv, Q Lv, R Cen, H Yi, M Wen, D Li, B Wu, D Wu, C Cao
    Lab. Invest., 2018-03-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice
    Authors: S Zambrano, PQ Rodriguez, J Guo, K Möller-Hac, A Schwarz, J Patrakka
    Sci Rep, 2018-03-16;8(1):4712.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Notch suppression collaborates with Ascl1 and Lin28 to unleash a regenerative response in fish retina, but not in mice
    Authors: F Elsaeidi, P Macpherson, EA Mills, J Jui, JG Flannery, D Goldman
    J. Neurosci., 2018-01-29;0(0):.
    Species: Zebrafish
    Sample Types: In Vivo
    Applications: In Vivo
  28. Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation
    Authors: T Tanaka, Y Zhou, T Ozawa, R Okizono, A Banba, T Yamamura, E Oga, A Muraguchi, H Sakurai
    J. Biol. Chem., 2017-12-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development
    Authors: S Kim, L Yang, S Kim, RG Lee, MJ Graham, JA Berliner, AJ Lusis, L Cai, RE Temel, DL Rateri, S Lee
    PLoS ONE, 2017-08-09;12(8):e0182566.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  30. Overactive EGFR Signaling Leads to Increased Fibrosis After SARS-CoV Infection
    Authors: T Venkataram, C Coleman, M Frieman
    J. Virol., 2017-05-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  31. ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis
    Authors: R Iwamoto, N Mine, H Mizushima, E Mekada
    J. Cell. Sci, 2017-02-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Arachidonate 12-Lipoxygenase Inhibitors Promote S100A3 Citrullination in Cultured SW480 Cells and Isolated Hair Follicles
    Authors: K Kizawa, T Fujimori, T Kawai
    Biol. Pharm. Bull., 2017-01-01;40(4):516-523.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes
    PLoS ONE, 2016-11-18;11(11):e0166710.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression
    J Exp Clin Cancer Res, 2016-09-26;35(1):151.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Excess HB-EGF, which promotes VEGF signaling, leads to hydrocephalus
    Authors: Joon W Shim
    Sci Rep, 2016-05-31;6(0):26794.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells.
    Authors: Veltmann M, Hollborn M, Reichenbach A, Wiedemann P, Kohen L, Bringmann A
    PLoS ONE, 2016-01-22;11(1):e0147312.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. RAF inhibitors that evade paradoxical MAPK pathway activation.
    Authors: Zhang C, Spevak W, Zhang Y, Burton E, Ma Y, Habets G, Zhang J, Lin J, Ewing T, Matusow B, Tsang G, Marimuthu A, Cho H, Wu G, Wang W, Fong D, Nguyen H, Shi S, Womack P, Nespi M, Shellooe R, Carias H, Powell B, Light E, Sanftner L, Walters J, Tsai J, West B, Visor G, Rezaei H, Lin P, Nolop K, Ibrahim P, Hirth P, Bollag G
    Nature, 2015-10-14;526(7574):583-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.
    Authors: Li D, Wang A, Liu X, Meisgen F, Grunler J, Botusan I, Narayanan S, Erikci E, Li X, Blomqvist L, DU L, Pivarcsi A, Sonkoly E, Chowdhury K, Catrina S, Stahle M, Landen N
    J Clin Invest, 2015-06-29;125(8):3008-26.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  39. Macrophages Regulate the Systemic Response to DNA Damage by a Cell Nonautonomous Mechanism.
    Authors: Geiger-Maor A, Guedj A, Even-Ram S, Smith Y, Galun E, Rachmilewitz J
    Cancer Res, 2015-05-14;75(13):2663-73.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
    Authors: Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D
    J Invest Dermatol, 2015-03-04;135(7):1771-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.
    Authors: Large M, Wetendorf M, Lanz R, Hartig S, Creighton C, Mancini M, Kovanci E, Lee K, Threadgill D, Lydon J, Jeong J, DeMayo F
    2014-06-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.
    Authors: Peterson J, Phelps E, Doll M, Schaal S, Ceresa B
    Invest Ophthalmol Vis Sci, 2014-05-01;55(5):2870-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.
    Authors: Cole C, Rushton G, Jayson G, Avizienyte E
    J Biol Chem, 2014-02-22;289(15):10488-501.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  44. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction.
    Authors: Shi, Chanjuan, Washington, M Kay, Chaturvedi, Rupesh, Drosos, Yiannis, Revetta, Frank L, Weaver, Connie J, Buzhardt, Emily, Yull, Fiona E, Blackwell, Timothy, Sosa-Pineda, Beatriz, Whitehead, Robert H, Beauchamp, R Daniel, Wilson, Keith T, Means, Anna L
    Lab Invest, 2014-02-17;94(4):409-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Alveolar progenitor and stem cells in lung development, renewal and cancer.
    Authors: Desai, Tushar J, Brownfield, Douglas, Krasnow, Mark A
    Nature, 2014-02-05;507(7491):190-4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Intranasal epidermal growth factor treatment rescues neonatal brain injury.
    Authors: Scafidi J, Hammond T, Scafidi S, Ritter J, Jablonska B, Roncal M, Szigeti-Buck K, Coman D, Huang Y, McCarter R, Hyder F, Horvath T, Gallo V
    Nature, 2013-12-25;506(7487):230-4.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  47. Live-cell fluorescence imaging reveals high stoichiometry of Grb2 binding to the EGF receptor sustained during endocytosis.
    Authors: Fortian A, Sorkin A
    J Cell Sci, 2013-11-20;127(0):432-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. STAT3 regulates uterine epithelial remodeling and epithelial-stromal crosstalk during implantation.
    Authors: Pawar S, Starosvetsky E, Orvis G, Behringer R, Bagchi I, Bagchi M
    Mol Endocrinol, 2013-10-07;27(12):1996-2012.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  49. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization.
    Authors: Zhang X, Liang X, Wang T, Liang X, Zuo R, Deng W, Zhang Z, Qin F, Zhao Z, Yang Z
    Mol Cell Endocrinol, 2013-08-29;381(1):272-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.
    Authors: Diaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge S
    J Cell Biol, 2013-04-15;201(2):279-92.
    Species: Human
    Sample Types: Whole Cells
  51. Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration.
    Authors: Nelson C, Ackerman K, O'Hayer P, Bailey T, Gorsuch R, Hyde D
    J Neurosci, 2013-04-10;33(15):6524-39.
    Species: Zebrafish
    Sample Types: In Vivo
    Applications: In Vivo
  52. Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia.
    Authors: Ray, K C, Moss, M E, Franklin, J L, Weaver, C J, Higginbotham, J, Song, Y, Revetta, F L, Blaine, S A, Bridges, L R, Guess, K E, Coffey, R J, Crawford, H C, Washington, M K, Means, A L
    Oncogene, 2013-02-04;33(7):823-31.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Bioassay
  53. Inhibition of putative hyalurosome platform in keratinocytes as a mechanism for corticosteroid-induced epidermal atrophy.
    Authors: Barnes L, Ino F, Jaunin F, Saurat J, Kaya G
    J Invest Dermatol, 2012-12-06;133(4):1017-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
    Authors: Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S
    Clin. Cancer Res., 2011-04-11;17(11):3619-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.
    Authors: Park JA, Drazen JM, Tschumperlin DJ
    J. Biol. Chem., 2010-07-22;285(39):29817-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Heparin binding epidermal growth factor in renal ischaemia/reperfusion injury.
    Authors: Mulder GM, Nijboer WN, Seelen MA, Sandovici M, Bos EM, Melenhorst WB, Trzpis M, Kloosterhuis NJ, Visser L, Henning RH, Leuvenink HG, Ploeg RJ, Sunnarborg SW, van Goor H
    J. Pathol., 2010-06-01;221(2):183-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth.
    Authors: Stoll SW, Johnson JL, Li Y, Rittie L, Elder JT
    J. Invest. Dermatol., 2010-04-29;130(8):2031-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Development and validation of sandwich ELISA microarrays with minimal assay interference.
    Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
    J. Proteome Res., 2008-04-19;7(6):2406-14.
    Applications: ELISA (Standard)
  59. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
    Authors: Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP
    Development, 2007-10-24;134(23):4177-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
    Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
    J. Biol. Chem., 2007-08-24;282(43):31643-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases.
    Authors: Zhu J, Jia X, Xiao G, Kang Y, Partridge NC, Qin L
    J. Biol. Chem., 2007-07-17;282(37):26656-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor.
    Authors: Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM
    Cancer Res., 2007-07-15;67(14):6760-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Epidermal growth factor-like growth factors prevent apoptosis of alcohol-exposed human placental cytotrophoblast cells.
    Authors: Wolff GS, Chiang PJ, Smith SM, Romero R, Armant DR
    Biol. Reprod., 2007-03-28;77(1):53-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
    Authors: Li F, Shetty AK, Sugahara K
    J. Biol. Chem., 2006-12-04;282(5):2956-66.
    Species: Fish - Prionace glauca (Blue Shark)
    Sample Types: Peptide
    Applications: Bioassay
  65. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
    Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
    J. Invest. Dermatol., 2006-05-11;126(9):2096-105.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor.
    Authors: Armant DR, Kilburn BA, Petkova A, Edwin SS, Duniec-Dmuchowski ZM, Edwards HJ, Romero R, Leach RE
    Development, 2006-01-11;133(4):751-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
    Authors: Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR
    Dev. Biol., 2004-02-15;266(2):223-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3.
    Authors: Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC
    Cancer Res., 2003-02-15;63(4):887-92.
    Species: Human
    Sample Types: Whole Cells

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Recombinant Human HB-EGF Protein
By Anonymous on 03/13/2020
Application: COMPONENT OF CELL CULTURE MEDIUM