Recombinant Human IFN-alpha 4b (alpha 4) Protein

Catalog #: 11180-1
2 Citations Datasheet / COA / SDS

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11180-1

R&D Systems Recombinant Proteins and Enzymes

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Citations (2)

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Recombinant Human IFN-alpha 4b (alpha 4) Protein Summary

Product Specifications

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Endotoxin Level

<1.0 EU per 1 μg of the protein by the LAL method.

Activity

Interferon was titrated with the use of the cytopathic effect inhibition assay as listed:

Bovine (MDBK/VSV) – performed as described [Rubinstein, et al. (1981) J. Virol. 37(2):755]. The EC₅₀ for interferon in this assay is ~5 U/ml. Lot Activity was derived from multiple determinations in the above assay.

Human (A549/EMCV) – performed as described [Budd, et al. (1985) Canc. Chem. Pharm. 12:39]. The EC₅₀ for interferon in this assay is ~1 U/ml.

Source

E. coli-derived human IFN-alpha 4 protein

Accession #

X02955

Predicted Molecular Mass

19.4 kDa

Product Datasheets

11180-1

Product Datasheet

COA

SDS

11180-1

Formulation	Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Shipping	The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:	Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Reconstitution Calculator

Background: IFN-alpha 4

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Long Name

Interferon alpha 4

Entrez Gene IDs

3441 (Human); 15967 (Mouse)

Alternate Names

IFNA4; IFNalpha 4; IFN-alpha 4; IFN-alpha-4; IFN-alpha4a; INFA4; interferon alpha-4; Interferon alpha-4B; Interferon alpha-76; Interferon alpha-M1; interferon, alpha 4; MGC142200

Related Research Areas

Interferons

Citations for Recombinant Human IFN-alpha 4b (alpha 4) Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells
Authors: I Pietrafort, A Butera, L Gaddini, A Mennella, R Palazzo, D Campanile, K Stefananto, V Riccieri, R Lande, L Frasca
International Journal of Molecular Sciences, 2022-12-30;24(1):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
Nature, 2012-07-26;487(7408):505-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay