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Recombinant Human IFN-beta 1a (Mammalian) Protein, CF

Catalog #: 11410-2
7 Citations Datasheet / COA / SDS
Newer Version Available: 8499-IF/CF
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Catalog # Availability Size / Price Qty
11410-2
R&D Systems Recombinant Proteins and Enzymes
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Product Details
Citations (7)
FAQs
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IFN-beta 1a (Mammalian) Protein, CF Summary

Product Specifications

Accession #
V00534

Product Datasheets

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11410-2

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

11410-2

Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Citations for Recombinant Human IFN-beta 1a (Mammalian) Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. Decreased expression of miR-29 family associated with autoimmune myasthenia gravis
    Authors: MA Cron, CA Payet, OM Fayet, S Maillard, F Truffault, E Fadel, J Guihaire, S Berrih-Akn, A Liston, R Le Panse
    J Neuroinflammation, 2020-10-08;17(1):294.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-beta Therapy.
    Authors: Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, Mari E, Safavi F, Leist T, Zhang G, Rostami A
    J Immunol, 2015-04-27;194(11):5085-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. A 20-amino-acid deletion in the neuraminidase stalk and a five-amino-acid deletion in the NS1 protein both contribute to the pathogenicity of H5N1 avian influenza viruses in mallard ducks.
    Authors: Li, Yanfang, Chen, Sujuan, Zhang, Xiaojian, Fu, Qiang, Zhang, Zhiye, Shi, Shaohua, Zhu, Yinbiao, Gu, Min, Peng, Daxin, Liu, Xiufan
    PLoS ONE, 2014-04-17;9(4):e95539.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Dual regulation of osteopontin production by TLR stimulation in dendritic cells.
    Authors: Salvi V, Scutera S, Rossi S, Zucca M, Alessandria M, Greco D, Bosisio D, Sozzani S, Musso T
    J Leukoc Biol, 2013-04-22;94(1):147-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses.
    Authors: Wang, Bei, Xi, Xueyan, Lei, Xiaobo, Zhang, Xiaoyan, Cui, Sheng, Wang, Jianwei, Jin, Qi, Zhao, Zhendong
    PLoS Pathog, 2013-03-21;9(3):e1003231.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  6. Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans.
    Authors: Popugaeva E, Witkowski PT, Schlegel M, Ulrich RG, Auste B, Rang A, Kruger DH, Klempa B
    PLoS ONE, 2012-04-24;7(4):e35587.
    Species: Human
    Sample Types: Whole Cells
    Applications: Control
  7. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines.
    Authors: Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K
    Genes Immun., 2009-10-01;10(8):702-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Why is recombinant Human Interferon-beta 1a (Catalog #'s 11415-1 and 11410-2) formulated with acetic acid?

    • Acetic acid was added to prevent aggregation.

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