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Recombinant Human PARP Enzyme

Catalog #: 4668-02K-01
3 Citations Datasheet / COA / SDS

Discontinued Product

4668-02K-01 has been discontinued.
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Citations (3)
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Summary Product Datasheets

Recombinant Human PARP Enzyme Summary

Provides the High specific activity PARP1 (PARP-HSA) is used in the Universal or PARP/Apoptosis Assay Kits.
 

Key Benefits

• Identification of inhibitors of PARP1 activity Quantitation of DNA Damage Investigation of PARP1 inactivation during apoptosis Western Blot Analysis

Substrate Specificity

PARP1 uses NAD+ as a substrate to catalyze poly(ADP-ribosyl)ation of target proteins involved  in  chromatin  structure  and  DNA  metabolism. PARP1 is stimulated by DNA-strand breaks and capable of auto-ribosylation.

Concentration

10 units/µl

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Limitations

For research use only. Not for diagnostic use.

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COA

Citations for Recombinant Human PARP Enzyme

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair
    Authors: D Munnur, J Somers, G Skalka, R Weston, R Jukes-Jone, M Bhogadia, C Dominguez, K Cain, I Ahel, M Malewicz
    Cell Rep, 2019-02-19;26(8):2028-2036.e6.  2019-02-19
  2. Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
    Authors: LM Polo, Y Xu, P Hornyak, F Garces, Z Zeng, R Hailstone, SJ Matthews, KW Caldecott, AW Oliver, LH Pearl
    Cell Rep, 2019-01-15;26(3):573-581.e5.  2019-01-15
  3. 2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation.
    Authors: MacPherson L, Tamblyn L, Rajendra S, Bralha F, McPherson J, Matthews J
    Nucleic Acids Res, 2012-12-28;41(3):1604-21.  2012-12-28

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