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Recombinant Human UbcH5a/UBE2D1 Protein, CF

Catalog #: E2-616
59 Citations Datasheet / COA / SDS
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E2-616-100
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Citations (59)
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Recombinant Human UbcH5a/UBE2D1 Protein, CF Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
Activity
Recombinant Human UbcH5a/UBE2D1 is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human UbcH5a/UBE2D1 concentration of 0.1-1 μM.
Source
E. coli-derived human UbcH5a/UBE2D1 protein
Met1 - Met147
Accession #
P51668.1
Predicted Molecular Mass
17 kDa

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E2-616

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

E2-616

Formulation Supplied as a solution in HEPES, NaCl, TCEP and Glycerol.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: UbcH5a/UBE2D1

Ubiquitin-conjugating Enzyme H5a (UbcH5a), also known as Ubiquitin-conjugating Enzyme E2D 1 (UBE2D1), is a ubiquitously expressed protein that is related to Stimulator of Iron Transport (SFT) (1,2). Human UbcH5a/UBE2D1 has a predicted molecular weight of 17 kDa and shares 89% and 88% amino acid (aa) sequence identity with the related family members UbcH5b and UbcH5c, respectively (3). Human UbcH5a/UBE2D1 shares 100% aa sequence identity with the mouse and rat orthologs. UbcH5a/UBE2D1 has a conserved E2 catalytic core domain that contains an active site cysteine residue, and it interacts with a variety of HECT and RING finger Ubiquitin ligases (E3) to mediate the ubiquitination of specific target proteins (4). UbcH5a/UBE2D1 interacts with the E3, E6-AP, to conjugate Ubiquitin to the tumor suppressor, p53 (1). Additional protein targets of UbcH5a/UBE2D1 include c-Fos, RIP1, and HIF-1 (5,6). Pathologically, UbcH5a/UBE2D1 is implicated in protein degradation during cancer and immune responses (7).

References
  1. Scheffner, M. et al. (1994) Proc. Natl. Acad. Sci. USA 91:8797.
  2. Gehrke, S. et al. (2003) Blood 101:3288.
  3. Jensen, J. et al. (1995) J. Biol. Chem. 270:30408.
  4. Lorick, K. et al. (2005) Methods Enzymol. 398:54.
  5. Stancovski, I. et al. (1995) Mol. Cell Biol. 15:7106.
  6. Dynek, J. et al. (2010) EMBO J. 29:4128.
  7. Vanni, E. et al. (2012) J. Virol. 86:6323.
Entrez Gene IDs
7321 (Human); 216080 (Mouse); 361831 (Rat)
Alternate Names
E2(17)KB1; Stimulator of Fe transportUBC4/5 homolog; UBC4/5; UBC5A; UbcH5; UbcH5a; UBCH5AEC 6.3.2.19; UBCH5SFT; UBE2D1; Ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2 D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase D1

Citations for Recombinant Human UbcH5a/UBE2D1 Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

59 Citations: Showing 1 - 10
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  1. VHL suppresses UBE3B-mediated breast tumor growth and metastasis
    Authors: Wang, S;Li, H;Liu, X;Yin, T;Li, T;Zheng, M;Liu, M;Meng, X;Zhou, J;Wang, Y;Chen, Y;
    Cell death & disease
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  2. Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF
    Authors: Radko-Juettner, S;Yue, H;Myers, JA;Carter, RD;Robertson, AN;Mittal, P;Zhu, Z;Hansen, BS;Donovan, KA;Hunkeler, M;Rosikiewicz, W;Wu, Z;McReynolds, MG;Roy Burman, SS;Schmoker, AM;Mageed, N;Brown, SA;Mobley, RJ;Partridge, JF;Stewart, EA;Pruett-Miller, SM;Nabet, B;Peng, J;Gray, NS;Fischer, ES;Roberts, CWM;
    Nature
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  3. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids
    Authors: Zhu, K;Suskiewicz, MJ;Chatrin, C;Strømland, Ø;Dorsey, BW;Aucagne, V;Ahel, D;Ahel, I;
    Nucleic acids research
    Species: N/A
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  4. Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
    Authors: Li, P;Zhen, Y;Kim, C;Liu, Z;Hao, J;Deng, H;Deng, H;Zhou, M;Wang, XD;Qin, T;Yu, Y;
    Science advances
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  5. PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target
    Authors: Singh, S;Yeat, NY;Wang, YT;Lin, SY;Kuo, IY;Wu, KP;Wang, WJ;Wang, WC;Su, WC;Wang, YC;Chen, RH;
    Cell death & disease
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  6. FBXO21 mediated degradation of p85? regulates proliferation and survival of acute myeloid leukemia
    Authors: Dobish, KK;Wittorf, KJ;Swenson, SA;Bean, DC;Gavile, CM;Woods, NT;Ghosal, G;Hyde, RK;Buckley, SM;
    Leukemia
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  7. Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1
    Authors: Meyers, M;Cismoski, S;Panidapu, A;Chie-Leon, B;Nomura, DK;
    bioRxiv : the preprint server for biology
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  8. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
    Authors: L Kong, C Sui, T Chen, L Zhang, W Zhao, Y Zheng, B Liu, X Cheng, C Gao
    Cell Reports, 2023-03-26;42(4):112306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  9. Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
    Authors: A Belmonte-F, J Herrero-Ru, M Galindo-Mo, MC Limón-Mort, M Mora-Santo, C Sáez, MÁ Japón, M Tortolero, F Romero
    Cell Death and Differentiation, 2022-12-08;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  10. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates
    Authors: K Zhu, MJ Suskiewicz, A Hloušek-Ka, H Meudal, A Miko?, V Aucagne, D Ahel, I Ahel
    Science Advances, 2022-10-05;8(40):eadd4253.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  11. Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia
    Authors: H Zhuang, Y Ren, C Mao, Y Zhong, Z Zhang, B Cao, Y Zhang, J Huang, G Xu, Z Huang, Y Xu, X Mao
    The Journal of Biological Chemistry, 2022-08-01;298(9):102314.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  12. The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
    Authors: X Ma, X Ma, L Zhu, Y Zhao, M Chen, T Li, Y Lin, D Ma, C Sun, L Han
    Oncogenesis, 2022-07-20;11(1):40.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  13. Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167
    Authors: K Ghilarducc, VC Cabana, A Harake, L Cappadocia, MP Lussier
    International Journal of Molecular Sciences, 2022-07-16;23(14):.
    Species: Human
    Sample Types: Recombinant Proteins
    Applications: Bioassay
  14. Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6
    Authors: D Deshmukh, J Xu, X Yang, H Shimelis, S Fang, Y Qiu
    Pharmaceutics, 2022-04-06;14(4):.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  15. Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes
    Authors: S Kaisari, S Miniowitz-, D Sitry-Shev, P Shomer, G Kozlov, K Gehring, A Hershko
    Proceedings of the National Academy of Sciences of the United States of America, 2022-03-01;119(9):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  16. Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway
    Authors: A Belmonte-F, J Herrero-Ru, M Galindo-Mo, MC Limón-Mort, M Mora-Santo, C Sáez, MÁ Japón, M Tortolero, F Romero
    Cell Death and Differentiation, 2022;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  17. ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB
    Authors: M Won, KA Park, S Kim, E Ju, Y Ko, H Yoo, H Ro, J Lee, J Oh, EG Lee, SY Kim, SW Nam, HM Shen, MK Yeo, JM Kim, GM Hur
    Cell Death and Differentiation, 2021-11-27;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  18. FBXL20 promotes breast cancer malignancy by inhibiting apoptosis through degradation of PUMA and BAX
    Authors: RK Manne, Y Agrawal, SK Malonia, S Banday, S Edachery, A Patel, A Kumar, P Shetty, MK Santra
    The Journal of Biological Chemistry, 2021-09-26;0(0):101253.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  19. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
    Authors: C Shen, A Nayak, LR Neitzel, AA Adams, M Silver-Ise, LM Sawyer, H Benchabane, H Wang, N Bunnag, B Li, DT Wynn, F Yang, M Garcia-Con, CH Williams, S Dakshanamu, CC Hong, NG Ayad, AJ Capobianco, Y Ahmed, E Lee, DJ Robbins
    Nature Communications, 2021-09-06;12(1):5263.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  20. PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
    Authors: Y Sun, J Chen, SN Huang, YP Su, W Wang, K Agama, S Saha, LM Jenkins, JM Pascal, Y Pommier
    Nature Communications, 2021-08-18;12(1):5010.
    Applications: Bioassay
  21. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain
    Authors: S Shukla, W Ying, F Gray, Y Yao, ML Simes, Q Zhao, H Miao, HJ Cho, P González-A, A Winkler, G Lund, T Purohit, E Kim, X Zhang, JM Ray, S He, C Nikolaidis, J Ndoj, J Wang, ? Jaremko, M Jaremko, RJH Ryan, ML Guzman, J Grembecka, T Cierpicki
    Nature Chemical Biology, 2021-06-21;17(7):784-793.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  22. K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty 2-mediated degradation of EGFR
    Authors: P Zhang, Z Zhang, Y Fu, Y Zhang, MP Washburn, L Florens, M Wu, C Huang, Z Hou, M Mohan
    Cell Death & Disease, 2021-06-11;12(6):608.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  23. Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12
    Authors: OM Khan, J Almagro, JK Nelson, S Horswell, V Encheva, KS Keyan, BE Clurman, AP Snijders, A Behrens
    Nature Communications, 2021-04-06;12(1):2043.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  24. BRCA1-BARD1 regulates transcription through BRD4 in Xenopus nucleoplasmic extract
    Authors: JK Barrows, G Fullbright, DT Long
    Nucleic Acids Research, 2021-04-06;0(0):.
    Species: N/A
    Sample Types: Plasmid
    Applications: Ubiquitination
  25. CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage
    Authors: MC Albert, K Brinkmann, W Pokrzywa, SD Günther, M Krönke, T Hoppe, H Kashkar
    Cell Death & Disease, 2020-09-10;11(9):740.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitylation
  26. PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis
    Authors: CR Kim, T Noda, H Kim, G Kim, S Park, Y Na, S Oura, K Shimada, I Bang, JY Ahn, YR Kim, SK Oh, HJ Choi, JS Kim, I Jung, H Lee, Y Okada, M Ikawa, SH Baek
    Cell Rep, 2020-07-28;32(4):107950.
    Species: Mouse
    Sample Types: Protein
    Applications: Bioassay
  27. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
    Authors: M S?abicki, Z Kozicka, G Petzold, YD Li, M Manojkumar, RD Bunker, KA Donovan, QL Sievers, J Koeppel, D Suchyta, AS Sperling, EC Fink, JA Gasser, LR Wang, SM Corsello, RS Sellar, M Jan, D Gillingham, C Scholl, S Fröhling, TR Golub, ES Fischer, NH Thomä, BL Ebert
    Nature, 2020-06-03;0(0):.
    Species: N/A
    Sample Types: Recombinant Protein
    Applications: Bioassay
  28. Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex
    Authors: ME Matyskiela, T Clayton, X Zheng, C Mayne, E Tran, A Carpenter, B Pagarigan, J McDonald, M Rolfe, LG Hamann, G Lu, PP Chamberlai
    Nat. Struct. Mol. Biol., 2020-04-06;27(4):319-322.
    Species: Spodoptera frugiperda
    Sample Types: Whole Cells
    Applications: Ubiquitination
  29. Competitive ubiquitination activates the tumor suppressor p53
    Authors: X Li, M Guo, L Cai, T Du, Y Liu, HF Ding, H Wang, J Zhang, X Chen, C Yan
    Cell Death Differ., 2019-12-02;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  30. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
    Authors: TC Ting, M Goralski, K Klein, B Wang, J Kim, Y Xie, D Nijhawan
    Cell Rep, 2019-11-05;29(6):1499-1510.e6.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  31. Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response
    Authors: J Sitz, SA Blanchet, SF Gameiro, E Biquand, TM Morgan, M Galloy, J Dessapt, EG Lavoie, A Blondeau, BC Smith, JS Mymryk, CA Moody, A Fradet-Tur
    Proc. Natl. Acad. Sci. U.S.A., 2019-09-09;116(39):19552-19562.
    Species: Virus - HPV
    Sample Types: Recombinant Protein
    Applications: Bioassay
  32. Mechanism for recycling tRNAs on stalled ribosomes
    Authors: MCJ Yip, AFA Keszei, Q Feng, V Chu, MJ McKenna, S Shao
    Nat. Struct. Mol. Biol., 2019-04-22;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  33. Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation
    Authors: G Lu, J Yi, A Gubas, YT Wang, Y Wu, Y Ren, M Wu, Y Shi, C Ouyang, HWS Tan, T Wang, L Wang, ND Yang, S Deng, D Xia, RH Chen, SA Tooze, HM Shen
    Autophagy, 2019-03-30;0(0):1-18.
    Applications: Bioassay
  34. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination
    Authors: OE Akande, PK Damle, M Pop, NE Sherman, BB Szomju, LV Litovchick, SR Grossman
    Cell Rep, 2019-03-19;26(12):3323-3335.e4.
    Applications: Bioassay
  35. Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome
    Authors: Y Dong, S Zhang, Z Wu, X Li, WL Wang, Y Zhu, S Stoilova-M, Y Lu, D Finley, Y Mao
    Nature, 2018-11-12;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  36. SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
    Authors: ME Matyskiela, S Couto, X Zheng, G Lu, J Hui, K Stamp, C Drew, Y Ren, M Wang, A Carpenter, CW Lee, T Clayton, W Fang, CC Lu, M Riley, P Abdubek, K Blease, J Hartke, G Kumar, R Vessey, M Rolfe, LG Hamann, PP Chamberlai
    Nat. Chem. Biol., 2018-09-06;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  37. Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF?-mediated apoptosis
    Authors: P Amin, M Florez, A Najafov, H Pan, J Geng, D Ofengeim, SA Dziedzic, H Wang, VJ Barrett, Y Ito, MJ LaVoie, J Yuan
    Proc. Natl. Acad. Sci. U.S.A., 2018-06-11;115(26):E5944-E5953.
    Applications: Bioassay
  38. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins
    Authors: R Khanna, V Krishnamoo, VK Parnaik
    FEBS J., 2018-05-03;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  39. CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells
    Authors: S Ito, A Ueno, T Ueda, H Nakagawa, H Taniguchi, N Kayukawa, A Fujihara-I, F Hongo, K Okihara, O Ukimura
    Oncotarget, 2018-04-03;9(25):17645-17655.
    Applications: Bioassay
  40. MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity inCaenorhabditis elegans
    Authors: M Ratliff, KL Hill-Harfe, EJ Gleason, H Ling, TL Kroft, SW L'Hernault
    Genetics, 2018-03-12;0(0):.
    Applications: Bioassay
  41. PI5P4K? functions in DTX1-mediated Notch signaling
    Authors: L Zheng, SD Conner
    Proc. Natl. Acad. Sci. U.S.A., 2018-02-12;0(0):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  42. Ubiquitin-dependent regulation of Cdc42 by XIAP
    Authors: A Murali, J Shin, H Yurugi, A Krishnan, M Akutsu, A Carpy, B Macek, K Rajalingam
    Cell Death Dis, 2017-06-29;8(6):e2900.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  43. DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues
    Authors: V Glorian, J Allègre, J Berthelet, B Dumetier, PM Boutanquoi, N Droin, C Kayaci, J Cartier, S Gemble, G Marcion, D Gonzalez, R Boidot, C Garrido, O Michaud, E Solary, L Dubrez
    Cell Death Dis, 2017-05-25;8(5):e2816.
    Species: Bacteria - E. Coli, Human
    Sample Types: Protein, Recombinant Protein
    Applications: Bioassay
  44. pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4(CRBN) ubiquitin ligase
    Authors: J An, CM Ponthier, R Sack, J Seebacher, MB Stadler, KA Donovan, ES Fischer
    Nat Commun, 2017-05-22;8(0):15398.
    Applications: Bioassay
  45. Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9
    Authors: CS Yang, K Jividen, A Spencer, N Dworak, L Ni, LT Oostdyk, M Chatterjee, B Ku?mider, B Reon, M Parlak, V Gorbunova, T Abbas, E Jeffery, NE Sherman, BM Paschal
    Mol. Cell, 2017-05-18;66(4):503-516.e5.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  46. Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination
    Authors: Y Lee, TF Chou, SK Pittman, AL Keith, B Razani, CC Weihl
    Cell Rep, 2017-04-04;19(1):188-202.
    Species: Mouse
    Sample Types: Protein, Whole Cells
    Applications: Bioassay
  47. Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry
    Authors: K Kliza, C Taumer, I Pinzuti, M Franz-Wach, S Kunzelmann, B Stieglitz, B Macek, K Husnjak
    Nat. Methods, 2017-03-20;0(0):.
    Applications: Bioassay
  48. Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms
    Authors: T Nakamura, K Murakami, H Tada, Y Uehara, J Nogami, K Maehara, Y Ohkawa, H Saitoh, H Nishitani, T Ono, R Nishi, M Yokoi, W Sakai, K Sugasawa
    Genes Cells, 2017-03-20;0(0):.
    Applications: Bioassay
  49. Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity
    Nucleic Acids Res., 2017-02-28;0(0):.
    Applications: Bioassay
  50. Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
    Nat Commun, 2016-07-28;7(0):12326.
    Applications: Bioassay
  51. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase
    Authors: Mary E Matyskiela
    Nature, 2016-06-22;0(0):.
    Applications: Bioassay
  52. The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1? sumoylation and poly-SUMO chain elongation
    Proc Natl Acad Sci USA, 2016-05-31;113(24):6725-30.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  53. A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum.
    Authors: Sanchez C, Liu C, Mayer S, Nurhasanah A, Cyrklaff M, Mu J, Ferdig M, Stein W, Lanzer M
    PLoS Genet, 2014-05-15;10(5):e1004382.
    Species: Parasite - Plasmodium falciparum
    Sample Types: Protein
    Applications: Bioassay
  54. Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
    Authors: Guicciardi, Maria Eu, Werneburg, Nathan W, Bronk, Steven F, Franke, Adrian, Yagita, Hideo, Thomas, Gary, Gores, Gregory
    PLoS ONE, 2014-03-14;9(3):e92124.
    Applications: Bioassay
  55. The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.
    Authors: Townley-Tilson, W H Davi, Wu, Yaxu, Ferguson, James E, Patterson, Cam
    PLoS ONE, 2014-02-21;9(2):e89451.
    Species: Human
    Sample Types: Whole Cells
    Applications: Ubiquitination
  56. A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.
    Authors: Hornburger M, Mayer B, Leonhardt S, Willer E, Zahler S, Beyerle A, Rajalingam K, Vollmar A, Furst R
    FASEB J, 2013-12-26;28(4):1938-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Ubiquitination
  57. Pin1 modulates ERalpha levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation.
    Authors: Rajbhandari P, Schalper K, Solodin N, Ellison-Zelski S, Ping Lu K, Rimm D, Alarid E
    Oncogene, 2013-04-01;33(11):1438-47.
    Applications: Bioassay
  58. C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog.
    Authors: Lee, Hyojin, Alpi, Arno F, Park, Mi So, Rose, Ann, Koo, Hyeon-So
    PLoS ONE, 2013-03-28;8(3):e60071.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Enzyme Assay
  59. Characterization of ML-IAP protein stability and physiological role in vivo.
    Authors: Varfolomeev, Eugene, Moradi, Elham, Dynek, Jasmin N, Zha, Jiping, Fedorova, Anna V, Deshayes, Kurt, Fairbrother, Wayne J, Newton, Kim, Le Couter, Jennifer, Vucic, Domagoj
    Biochem J, 2012-11-01;447(3):427-36.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay

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