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Recombinant Mouse CCL2/JE/MCP-1 Protein

Catalog #: 479-JE
97 Citations 7 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
479-JE-010/CF
479-JE-050/CF

With Carrier

Catalog # Availability Size / Price Qty
479-JE-010
479-JE-050
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Recombinant Mouse CCL2/JE/MCP-1 Protein Bioactivity
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Product Details
Citations (97)
FAQs
Reviews (7)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse CCL2/JE/MCP-1 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR2A. The ED50 for this effect is typically 2-10 ng/mL.
Source
E. coli-derived mouse CCL2/JE/MCP-1 protein
Gln24-Arg96
Accession #
Q5SVU3
N-terminal Sequence
Analysis
Gln24
Predicted Molecular Mass
8.5 kDa

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479-JE (with carrier)

Product Datasheet
COA
SDS

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479-JE/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

479-JE

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

479-JE/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse CCL2/JE/MCP-1 Protein Bioactivity View Larger

Recombinant Mouse CCL2/JE/MCP-1 (Catalog # 479-JE) chemoattracts the BaF3 mouse pro-B cell line transfected with human CCR2A. The ED50 for this effect is 2-10 ng/mL.

SDS-PAGE Recombinant Mouse CCL2/JE/MCP-1 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse CCL2/JE/MCP-1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band at 8 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: CCL2/JE/MCP-1

CCL2, also called monocyte chemotactic protein-1 (MCP-1) or JE, is a member of the C-C or beta  chemokine family that is best known as a chemotactic agent for mononuclear cells (1, 2). Mouse CCL2 cDNA encodes a 148 amino acid (aa) precursor protein with a 23 aa signal peptide and a 125 aa mature protein (1). Removal of the first 5 aa of the mature protein, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, occurs naturally by metalloproteinase cleavage and downregulates activity but not receptor binding (3). Mouse CCL2 forms a broad band around 25 kDa on SDS-PAGE due to non-covalent dimerization and variable carbohydrate content (1). Mouse and rat express a form of CCL2 that is extended by 49 aa compared to other species. Mature mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively, over aa 24 ‑ 101.  Human CCL2 can, however, induce a limited response in rodent cells, and mouse CCL2 has full activity on human cells (2, 4). Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source (1, 2). In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2 (2). Additionally, it promotes Th2 polarization in CD4+ T cells (5). CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma (6, 7). When a DNA sequence encoding the 125 aa residue of the mature CCL2 protein was expressed in E. coli at R&D Systems, the purified protein had the predicted N-terminus but a mass of 8525 Da. The truncation of most of the C-terminal extension could be due either to purification artifact or to post-translational modification. The truncated recombinant CCL2 has a potency similar to that of human MCP-1 in the monocyte chemotaxis assay.

References
  1. Rollins, B.J. et al. (1988) Proc. Natl. Acad. Sci. USA. 85:3738.
  2. Deshmane, S.L. et al. (2009) J. Interferon Cytokine Res. 29:313.
  3. Dean, R.A. et al. (2008) Blood. 112:3455.
  4. Van Riper, G. et al. (1993) J. Exp. Med. 177:851.
  5. Luther, S.A. and J.G. Cyster (2001) Nat. Immunol. 2:102.
  6. Daly, C. et al. (2003) Microcirculation 10:247.
  7. Aukrust, P. et al. (2008) Arterioscler. Thromb. Vasc. Biol. 28:1909.
Entrez Gene IDs
6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
Alternate Names
C-C motif chemokine ligand 2; CCL2; GDCF-2; HC11; HSMCR30; MCAF; Mcp1; MCP-1; SCYA2; SMC-CF

Citations for Recombinant Mouse CCL2/JE/MCP-1 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

97 Citations: Showing 1 - 10
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  1. C-C chemokine ligand 2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor mouse models
    Authors: Alissa, N;Fang, WB;Medrano, M;Bergeron, N;Kozai, Y;Hu, Q;Redding, C;Thyfault, J;Reeves, JH;Berkland, C;Cheng, N;
    Disease models & mechanisms
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  2. Sepsis-trained macrophages promote antitumoral tissue-resident T cells
    Authors: Broquet, A;Gourain, V;Goronflot, T;Le Mabecque, V;Sinha, D;Ashayeripanah, M;Jacqueline, C;Martin, P;Davieau, M;Boutin, L;Poulain, C;Martin, FP;Fourgeux, C;Petrier, M;Cannevet, M;Leclercq, T;Guillonneau, M;Chaumette, T;Laurent, T;Harly, C;Scotet, E;Legentil, L;Ferrières, V;Corgnac, S;Mami-Chouaib, F;Mosnier, JF;Mauduit, N;McWilliam, HEG;Villadangos, JA;Gourraud, PA;Asehnoune, K;Poschmann, J;Roquilly, A;
    Nature immunology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation
    Authors: Hong, J;Son, M;Sin, J;Kim, H;Chung, DK;
    Nutrients
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Control
  4. Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release
    Authors: Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. VDUP1 Deficiency Promotes the Severity of DSS-Induced Colitis in Mice by Inducing Macrophage Infiltration
    Authors: Park, KH;Lee, H;Kim, HC;Choi, I;Han, SB;Kang, JS;
    International journal of molecular sciences
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis
    Authors: Han, Y;Tomita, T;Kato, M;Ashihara, N;Higuchi, Y;Matoba, H;Wang, W;Hayashi, H;Itoh, Y;Takahashi, S;Kurita, H;Nakayama, J;Okumura, N;Hiratsuka, S;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  7. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
    Authors: Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan
    PLoS ONE, 2023-01-20;18(1):e0280590.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  8. Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity
    Authors: J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao
    Cell Reports, 2023-01-18;42(1):111991.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease
    Authors: A Rajesh, S Droho, JA Lavine
    Journal of Neuroinflammation, 2022-08-08;19(1):203.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  10. Microglia coordinate cellular interactions during spinal cord repair in mice
    Authors: FH Brennan, Y Li, C Wang, A Ma, Q Guo, Y Li, N Pukos, WA Campbell, KG Witcher, Z Guan, KA Kigerl, JCE Hall, JP Godbout, AJ Fischer, DM McTigue, Z He, Q Ma, PG Popovich
    Oncogene, 2022-07-14;13(1):4096.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  11. Histone functions as a cell-surface receptor for AGEs
    Authors: M Itakura, K Yamaguchi, R Kitazawa, SY Lim, Y Anan, J Yoshitake, T Shibata, L Negishi, H Sugawa, R Nagai, K Uchida
    Nature Communications, 2022-05-27;13(1):2974.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Hypoxia-reprogrammed regulatory group 2 innate lymphoid cells promote immunosuppression in pancreatic cancer
    Authors: L Ye, K Jin, Z Liao, Z Xiao, H Xu, X Lin, H Li, T Li, W Zhang, X Han, W Wang, H Gao, L Liu, W Wu, X Yu
    EBioMedicine, 2022-04-25;79(0):104016.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner
    Authors: YJ Ahn, L Wang, S Tavakoli, HN Nguyen, JD Short, R Asmis
    Nature Communications, 2022-02-10;13(1):790.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Selective Immune Modulating Activities of Viscum album and Its Components; A Possibility of Therapeutics on Skin Rash Induced by EGFR Inhibitors
    Authors: HJ Choi, SJ Park, YN Choi, SD Kim, EB Kwag, SY Song, JH Park, JK Kim, C Seo, JJ Choi, HS Yoo
    Integrative cancer therapies, 2022-01-01;21(0):1534735422111.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Investigation of Anti-Tumor Effects of an MLK1 Inhibitor in Prostate and Pancreatic Cancers
    Authors: YC Fan, KC Hsu, TE Lin, D Zechner, SP Hsu, YC Tsai
    Biology, 2021-08-02;10(8):.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
    Authors: LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller
    Nature Communications, 2021-06-10;12(1):3543.
    Species: Mouse
    Sample Types: Exosomes
    Applications: ELISA Capture
  17. The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice
    Authors: S Ishihara, AM Obeidat, DL Wokosin, D Ren, RJ Miller, AM Malfait, RE Miller
    Arthritis Research & Therapy, 2021-04-07;23(1):103.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  18. Pertussis Toxin Inhibits Encephalitogenic T-Cell Infiltration and Promotes a B-Cell-Driven Disease during Th17-EAE
    Authors: Z Maria, E Turner, A Agasing, G Kumar, RC Axtell
    International Journal of Molecular Sciences, 2021-03-13;22(6):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair
    Authors: A Villarreal, MW Tiruneh, J Lee, CF Guerrero-J, J Kuhn, JA David, K Dammeyer, R Mc Kell, J Kwong, PS Rabbani, Q Nie, DJ Ceradini
    Cell Rep, 2020-11-24;33(8):108417.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  20. -->The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently upregulated in mice after traumatic brain injury, and CCL2 modulates the complement system in microglia
    Authors: K Popiolek-B, A Ciechanows, K Ciapa?a, K Pawlik, M Oggioni, D Mercurio, MG De Simoni, J Mika
    Mol Cell Probes, 2020-11-04;54(0):101671.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. YAP and TAZ protect against white adipocyte cell death during obesity
    Authors: L Wang, S Wang, Y Shi, R Li, S Günther, YT Ong, M Potente, Z Yuan, E Liu, S Offermanns
    Nat Commun, 2020-10-28;11(1):5455.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
    Authors: K Wang, Y Gu, Y Liao, S Bang, CR Donnelly, O Chen, X Tao, AJ Mirando, MJ Hilton, RR Ji
    J. Clin. Invest., 2020-07-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Macrophage HIV-1 Gene Expression and Delay Resolution of Inflammation in HIV-Tg Mice
    Authors: M Jerebtsova, A Ahmad, N Kumari, O Rutagarama, S Nekhai
    Viruses, 2020-03-01;12(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. HIV-1 Transcription Inhibitor 1E7-03 Restores LPS-Induced Alteration of Lung Leukocytes' Infiltration Dynamics and Resolves Inflammation in HIV Transgenic Mice
    Authors: M Jerebtsova, A Ahmad, X Niu, O Rutagarama, S Nekhai
    Viruses, 2020-02-12;12(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia
    Authors: GB Kitchen, PS Cunningham, TM Poolman, M Iqbal, R Maidstone, M Baxter, J Bagnall, N Begley, B Saer, T Hussell, LC Matthews, DH Dockrell, HJ Durrington, JE Gibbs, JF Blaikley, AS Loudon, DW Ray
    Proc. Natl. Acad. Sci. U.S.A., 2020-01-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. Chemokine-Binding Proteins Encoded by Parapoxvirus of Red Deer of New Zealand Display Evidence of Gene Duplication and Divergence of Ligand Specificity
    Authors: S Sharif, N Ueda, Y Nakatani, LM Wise, S Clifton, Z Lateef, AA Mercer, SB Fleming
    Front Microbiol, 2019-06-25;10(0):1421.
    Species: Mouse
    Sample Types:
    Applications: Binding Assay
  27. Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia
    Authors: K Kwiatkowsk, K Popiolek-B, A Piotrowska, E Rojewska, K Ciapa?a, W Makuch, J Mika
    Cytokine, 2019-04-16;119(0):202-213.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  28. Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis
    Authors: M Qiu, K Huang, Y Liu, Y Yang, H Tang, X Liu, C Wang, H Chen, Y Xiong, J Zhang, J Yang
    Mucosal Immunol, 2019-02-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Bone Marrow Mesenchymal Stromal Cell-Derived Periostin Promotes B-ALL Progression by Modulating CCL2 in Leukemia Cells
    Authors: Z Ma, X Zhao, M Deng, Z Huang, J Wang, Y Wu, D Cui, Y Liu, R Liu, G Ouyang
    Cell Rep, 2019-02-05;26(6):1533-1543.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Phagocytosis of Leptospira by leukocytes from mice with different susceptibility to leptospirosis and possible role of chemokines
    Authors: PLD Silva, F Lauretti-F, M Caldas de, SS Lima, AE Covarrubia, M De Franco, E Carvalho, PL Ho, RMA da Costa, EAL Martins, JB Da Silva
    BMC Microbiol., 2019-01-07;19(1):4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
    Authors: T Kubota, M Inoue, N Kubota, I Takamoto, T Mineyama, K Iwayama, K Tokuyama, M Moroi, K Ueki, T Yamauchi, T Kadowaki
    Nat Commun, 2018-11-19;9(1):4863.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2
    Authors: S Lee, JS Kong, S You, HM Kwon, SA Yoo, CS Cho, WU Kim
    J. Immunol., 2018-05-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis
    Authors: A Zou, N Magee, F Deng, S Lehn, C Zhong, Y Zhang
    J. Biol. Chem., 2018-04-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Smurf1 regulates macrophage proliferation, apoptosis and migration via JNK and p38 MAPK signaling pathways
    Authors: J Guo, X Qiu, L Zhang, R Wei
    Mol. Immunol., 2018-03-15;97(0):20-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections
    Authors: V Johnson, T Webb, A Norman, J Coy, J Kurihara, D Regan, S Dow
    Sci Rep, 2017-08-29;7(1):9575.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization
    Authors: C Freitas, M Wittner, J Nguyen, V Rondeau, V Biajoux, ML Aknin, F Gaudin, S Beaussant-, Y Bertrand, C Bellanné-C, J Donadieu, F Bachelerie, M Espéli, A Dalloul, F Louache, K Balabanian
    J. Exp. Med., 2017-05-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing
    Authors: K Hosaka, K Rojas, HZ Fazal, MB Schneider, J Shores, V Federico, M McCord, L Lin, B Hoh
    Stroke, 2017-03-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Scavenger receptor A1 prevents metastasis of non-small cell lung cancer via suppression of macrophage serum amyloid A1
    Authors: Y Zhang, Y Wei, B Jiang, L Chen, H Bai, X Zhu, X Li, H Zhang, Q Yang, J Ma, Y Xu, J Ben, DC Christiani, Q Chen
    Cancer Res, 2017-02-15;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung
    Authors: H Nakano, MR Lyons-Cohe, GS Whitehead, K Nakano, DN Cook
    J. Leukoc. Biol, 2017-02-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo
    Authors: N Lavender, J Yang, SC Chen, J Sai, CA Johnson, P Owens, GD Ayers, A Richmond
    BMC Cancer, 2017-01-31;17(1):88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
    Nat Commun, 2016-12-21;7(0):13781.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
    Mucosal Immunol, 2016-11-09;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  43. High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis
    Authors: Cong Lin
    J Cell Mol Med, 2016-06-14;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Platelets Guide Leukocytes to Their Sites of Extravasation
    PLoS Biol, 2016-05-06;14(5):e1002459.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  45. PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice
    Authors: T Wang, Z Wang, P Yang, L Xia, M Zhou, S Wang, J Du, J Zhang
    Cell Death Dis, 2016-04-07;7(0):e2176.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease.
    Authors: Baek J, Zeng R, Weinmann-Menke J, Valerius M, Wada Y, Ajay A, Colonna M, Kelley V
    J Clin Invest, 2015-06-29;125(8):3198-214.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Murine IL-17+ Vgamma4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis.
    Authors: Costa M, de Negreiros C, Bornstein V, Valente R, Mengel J, Henriques M, Benjamim C, Penido C
    BMC Immunol, 2015-06-03;16(0):36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration.
    Authors: Eguchi A, Mulya A, Lazic M, Radhakrishnan D, Berk M, Povero D, Gornicka A, Feldstein A
    PLoS ONE, 2015-04-07;10(4):e0123110.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Combined effect of insulin-like growth factor-1 and CC chemokine ligand 2 on angiogenic events in endothelial cells.
    Authors: Viana I, de Almeida M, Lins M, dos Santos Reis M, de Araujo Vieira L, Smaniotto S
    PLoS ONE, 2015-04-01;10(4):e0121249.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Chemokine-coupled beta2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.
    Authors: Morrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J
    J Exp Med, 2014-09-01;211(10):1957-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney.
    Authors: Sato S, Zhang X
    Clin Exp Immunol, 2014-07-01;177(1):102-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Cancer affects microRNA expression, release, and function in cardiac and skeletal muscle.
    Authors: Chen D, Goswami C, Burnett R, Anjanappa M, Bhat-Nakshatri P, Muller W, Nakshatri H
    Cancer Res, 2014-06-30;74(16):4270-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. CXCR4 chemokine receptor signaling mediates pain in diabetic neuropathy.
    Authors: Menichella D, Abdelhak B, Ren D, Shum A, Frietag C, Miller R
    Mol Pain, 2014-06-25;10(0):42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.
    Authors: Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G
    Stem Cells, 2014-05-01;32(5):1347-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion.
    Authors: Fleetwood A, Achuthan A, Schultz H, Nansen A, Almholt K, Usher P, Hamilton J
    J Immunol, 2014-03-10;192(8):3540-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.
    Authors: Ramkhelawon B, Hennessy E, Menager M, Ray T, Sheedy F, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner K, Moore K
    Nat Med, 2014-03-02;20(4):377-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.
    Authors: Kallis, Yiannis, Scotton, Christop, Mackinnon, Alison C, Goldin, Robert D, Wright, Nicholas, Iredale, John P, Chambers, Rachel C, Forbes, Stuart J
    PLoS ONE, 2014-01-27;9(1):e86241.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103+ dendritic cells to the colon in response to Trichuris muris infection.
    Authors: Bowcutt, R, Bramhall, M, Logunova, L, Wilson, J, Booth, C, Carding, S R, Grencis, R, Cruickshank, S
    Mucosal Immunol, 2014-01-22;7(5):1094-105.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Technical advance: monitoring the trafficking of neutrophil granulocytes and monocytes during the course of tissue inflammation by noninvasive 19F MRI.
    Authors: Temme S, Jacoby C, Ding Z, Bonner F, Borg N, Schrader J, Flogel U
    J Leukoc Biol, 2013-12-06;95(4):689-97.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  60. A circadian clock gene, Rev-erbalpha, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
    Authors: Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T
    J Immunol, 2013-12-04;192(1):407-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  61. Defective TGF-beta signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors.
    Authors: Fan Q, Gu D, Liu H, Yang L, Zhang X, Yoder M, Kaplan M, Xie J
    Cancer Res, 2013-11-26;74(2):471-83.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
    Authors: Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K
    PLoS ONE, 2013-11-18;8(11):e80500.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Deletion of class A scavenger receptor deteriorates obesity-induced insulin resistance in adipose tissue.
    Authors: Zhu, Xudong, Zong, Guijuan, Zhu, Liu, Jiang, Yuchen, Ma, Ke, Zhang, Hanwen, Zhang, Yan, Bai, Hui, Yang, Qing, Ben, Jingjing, Li, Xiaoyu, Xu, Yong, Chen, Qi
    Diabetes, 2013-10-29;63(2):562-77.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention.
    Authors: Wanschel, Amarylis, Seibert, Tara, Hewing, Bernd, Ramkhelawon, Bhama, Ray, Tathagat, van Gils, Janine M, Rayner, Katey J, Feig, Jonathan, O'Brien, Edward R, Fisher, Edward A, Moore, Kathryn
    Arterioscler Thromb Vasc Biol, 2013-02-21;33(5):886-93.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
    Authors: Kim HS, Go H, Akira S, Chung DH
    J. Immunol., 2011-09-19;187(8):4007-17.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  66. Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy.
    Authors: Guerrot D, Kerroch M, Placier S, Vandermeersch S, Trivin C, Mael-Ainin M, Chatziantoniou C, Dussaule JC
    Am. J. Pathol., 2011-05-13;179(1):83-91.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  67. Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.
    Authors: Russo RC, Garcia CC, Barcelos LS, Rachid MA, Guabiraba R, Roffe E, Souza AL, Sousa LP, Mirolo M, Doni A, Cassali GD, Pinho V, Locati M, Teixeira MM
    J. Leukoc. Biol., 2010-11-02;89(2):269-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2.
    Authors: Koth LL, Cambier CJ, Ellwanger A
    J. Immunol., 2010-04-26;184(11):6522-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice.
    Authors: Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M
    Endocrinology, 2010-01-07;151(3):971-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  70. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression.
    Authors: Fujimoto H, Sangai T, Ishii G, Ikehara A, Nagashima T, Miyazaki M, Ochiai A
    Int. J. Cancer, 2009-09-15;125(6):1276-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice.
    Authors: Lafdil F, Chobert MN, Deveaux V, Zafrani ES, Mavier P, Nakano T, Laperche Y, Brouillet A
    J. Hepatol., 2009-04-22;51(1):55-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain.
    Authors: Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ, Park JY, Lind AL, Ma Q, Ji RR
    J. Neurosci., 2009-04-01;29(13):4096-108.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  73. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
    Authors: Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T
    Immunology, 2008-04-03;125(2):272-9.
    Applications: ELISA (Standard)
  74. Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
    Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
    Nature, 2007-12-06;450(7171):825-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway.
    Authors: Penido C, Costa MF, Souza MC, Costa KA, Candea AL, Benjamim CF, Henriques MG
    Int. Immunol., 2007-12-04;20(1):129-39.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  76. Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages.
    Authors: Kang JH, Kim CS, Han IS, Kawada T, Yu R
    FEBS Lett., 2007-08-14;581(23):4389-96.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Histone H2B as a functionally important plasminogen receptor on macrophages.
    Authors: Das R, Burke T, Plow EF
    Blood, 2007-08-09;110(10):3763-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.
    Authors: Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA
    Am. J. Respir. Cell Mol. Biol., 2007-04-19;37(2):248-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. High pressure promotes monocyte adhesion to the vascular wall.
    Authors: Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S
    Circ. Res., 2007-03-29;100(8):1226-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. The binding of CCL2 to the surface of Trypanosoma cruzi induces chemo-attraction and morphogenesis.
    Authors: Yamauchi LM, Aliberti JC, Baruffi MD, Portela RW, Rossi MA, Gazzinelli RT, Mineo JR, Silva JS
    Microbes Infect., 2006-12-08;9(1):111-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  81. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
    Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
    J. Immunol., 2006-08-01;177(3):1967-74.
    Applications: ELISA (Standard)
  82. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.
    Authors: Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, Stratis A, Renkl AC, Sunderkotter C, Wlaschek M, Haase I, Scharffetter-Kochanek K
    J. Clin. Invest., 2006-08-01;116(8):2105-14.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  83. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury.
    Authors: Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA
    J. Immunol., 2006-07-01;177(1):612-20.
    Applications: ELISA (Standard)
  84. The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines.
    Authors: Rhodes KE, Raivich G, Fawcett JW
    Neuroscience, 2006-04-21;140(1):87-100.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  85. Sequential ELISA to profile multiple cytokines from small volumes.
    Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
    J. Immunol. Methods, 2005-07-01;302(1):172-81.
    Applications: ELISA (Standard)
  86. Antibody-bound beta-amyloid precursor protein stimulates the production of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 by cortical neurons.
    Authors: Gonzalez de Aguilar JL, Dupuis L, Larmet Y
    Neurobiol. Dis., 2005-06-01;19(1):129-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
    Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A
    Am. J. Respir. Cell Mol. Biol., 2005-05-18;33(3):248-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Selective macrophage suppression during sepsis.
    Authors: Ellaban E, Bolgos G, Remick D
    Cell. Immunol., 2005-02-26;231(1):103-11.
    Applications: ELISA (Standard)
  89. Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
    Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
    Brain, 2005-02-02;128(0):854-66.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  90. The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
    Authors: Ueno T, Kuse S, Saito F, Nitta T, Kakiuchi T, Hollander GA, Takahama Y
    Blood, 2004-09-09;105(1):31-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells.
    Authors: Bengtsson AK, Ryan EJ, Giordano D, Magaletti DM, Clark EA
    Blood, 2004-05-13;104(5):1404-10.
    Applications: ELISA (Standard)
  92. IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1.
    Authors: Russell TD, Yan Q, Fan G, Khalifah AP, Bishop DK, Brody SL, Walter MJ
    J. Immunol., 2003-12-15;171(12):6866-74.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guerin.
    Authors: Penido C, Vieira-de-Abreu A, Bozza MT, Castro-Faria-Neto HC, Bozza PT
    J. Immunol., 2003-12-15;171(12):6788-94.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  94. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.
    Authors: Bruemmer D, Collins AR, Noh G, Wang W, Territo M, Arias-Magallona S, Fishbein MC, Blaschke F, Kintscher U, Graf K, Law RE, Hsueh WA
    J. Clin. Invest., 2003-11-01;112(9):1318-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity.
    Authors: Hieshima K, Ohtani H, Shibano M, Izawa D, Nakayama T, Kawasaki Y, Shiba F, Shiota M, Katou F, Saito T, Yoshie O
    J. Immunol., 2003-02-01;170(3):1452-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Possible co-regulation of genes associated with enhanced progression of mammary adenocarcinomas.
    Authors: Neumark E, Cohn MA, Lukanidin E, Witz IP, Ben-Baruch A
    Immunol. Lett., 2002-06-03;82(1):111-21.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  97. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.
    Authors: Maus UA, Koay MA, Delbeck T, Mack M, Ermert M, Ermert L, Blackwell TS, Christman JW, Schlondorff D, Seeger W, Lohmeyer J
    Am. J. Physiol. Lung Cell Mol. Physiol., 2002-06-01;282(6):L1245-52.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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