Recombinant Mouse Reg2 Protein, CF Summary
Product Specifications
Gln23-Ala173, with an N-terminal Met
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
2098-RG
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 500 μg/mL in PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: Reg2
Mouse Reg2 (Islets of Langerhans regenerating protein 2), also known as Reg‑II, Lithostathine 2, PTP2 (pancreatic thread protein 2) and PSP2 (pancreatic stone protein 2), is a member of the Reg family of secreted C‑type lectin domain‑containing pancreatic proteins (1, 2). Reg2 forms a subfamily with mouse and human Reg1 molecules (1). The mouse Reg2 cDNA encodes 173 amino acids (aa) including the 22 aa signal sequence and the 151 aa secreted mature protein. Mouse Reg2 shares approximately 83% aa sequence identity with hamster Reg2, but no Reg2 ortholog exists in humans or rats (1, 2). Reg proteins are thought to be stress response proteins that stimulate proliferation, particularly in beta cells of pancreatic islets (1). Reg2 is expressed primarily by acinar cells in the normal exocrine pancreas, and is up‑regulated in NOD (non-obese diabetic) islets, hyperplastic islets, regenerating islets or in response to pancreatic injury or pancreatitis (1‑5). IFN‑ beta causes Reg2 up‑regulation in early‑onset diabetic NOD mice or in a NOD insulinoma cell line (4). Reg2 is also up‑regulated in mice lacking the pancreas‑expressed keratin K8, and is thought to be regulated by keratin filament organization (3). It is proposed to serve as an autoantigen in NOD mouse immune‑mediated type I diabetes models (4).
- Liu, J.-L. et al. (2008) Endocrine Metab. Immune Disord. Drug Targets 8:1.
- Unno, M. et al. (1993) J. Biol. Chem. 268:15974.
- Zhong, B. et al. (2007) Mol. Biol. Cell 18:4969.
- Gurr, W. et al. (2007) Diabetes 56:34.
- Lu, Y. et al. (2006) Am. J. Physiol. Endocrinol. Metab. 291:E50.
- Baeza, N. et al. (1997) FEBS Lett. 416:364.
- Planas, R. et al. (2006) Diabetologia 49:2379.
Citation for Recombinant Mouse Reg2 Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes
Authors: Zhu, S;Waeckel-Énée, E;Moser, A;Bessard, MA;Roger, K;Lipecka, J;Yilmaz, A;Bertocci, B;Diana, J;Saintpierre, B;Guerrera, IC;Francesconi, S;Mauvais, FX;van Endert, P;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Recombinant Protein
Applications: Bioassay
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