Ro 0437626
Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide
Purity: ≥98%
Biological Activity
Ro 0437626 is a selective P2X1 purinergic receptor antagonist (IC50 = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and synthesis of a novel and selective drug-like P2X1 antagonist.
Jaime-Figueroa et al.
Bioorg.Med.Chem.Lett., 2005;15:3292 -
Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats.
King et al.
Br.J.Pharmacol., 2004;142:519 -
Purinoceptors as therapeutic targets for lower urinary tract dysfunction.
Ford et al.
Br.J.Pharmacol., 2006;147:S132
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