Home / Benzodiazepine Inverse Agonists / Ro 15-4513

Ro 15-4513

Catalog #: 1997
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1997/50
1997/10
Ro 15-4513 | CAS No. 91917-65-6 | Benzodiazepine Inverse Agonists
1 Image
Description: Benzodiazepine partial inverse agonist

Chemical Name: 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Technical Data

M.Wt:
326.31
Formula:
C15H14N6O3
Solubility:
Soluble to 5 mM in ethanol and to 10 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
91917-65-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Ro 15-4513

The citations listed below are publications that use Tocris products. Selected citations for Ro 15-4513 include:

2 Citations: Showing 1 - 2

  1. Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
    Authors: Tracy Et al.
    Psychopharmacology  2016;233:715
  2. Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment.
    Authors: Koh Et al.
    J Neurosci  2013;64:145

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Ro 15-4513

There are currently no reviews for this product. Be the first to review Ro 15-4513 and earn rewards!

Have you used Ro 15-4513?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.