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Rose Bengal

Catalog #: 5168
2 Citations Datasheet / COA / SDS

Discontinued Product

5168 has been discontinued.
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Rose Bengal | CAS No. 632-69-9 | Glutamate (EAAT) Transporter Inhibitors
1 Image
Description: Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor

Chemical Name: 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.

Technical Data

M.Wt:
1017.64
Formula:
C20H2Cl4I4Na2O5
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
632-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Rose Bengal

The citations listed below are publications that use Tocris products. Selected citations for Rose Bengal include:

2 Citations: Showing 1 - 2

  1. Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke.
    Authors: Richard Et al.
    iScience  2022;25:103539
  2. Perivascular Adipocytes Store Norepinephrine by Vesicular Transport.
    Authors: Ahmad Et al.
    Arterioscler Thromb Vasc Biol  2019;39:188

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