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(R,R)-THC

Catalog #: 1990
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1990/10
(R,R)-THC | CAS No. 138090-06-9 | Additional Estrogen and Related Receptor Compounds
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Description: Potent subtype-selective ligand; ERα agonist/ERβ antagonist

Chemical Name: (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol

Purity: ≥98%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).

Technical Data

M.Wt:
320.42
Formula:
C22H24O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
138090-06-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (R,R)-THC

The citations listed below are publications that use Tocris products. Selected citations for (R,R)-THC include:

8 Citations: Showing 1 - 8

  1. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system.
    Authors: Kola Et al.
    PLoS One  ;3:e1797
  2. Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling?
    Authors: Vona Et al.
    Cell Physiol Biochem  2019;53:186
  3. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α.
    Authors: Wang Et al.
    Drug Des Devel Ther  2015;9:3755
  4. Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
    Authors: Nicholson Et al.
    PLoS One  2015;193:722
  5. Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells.
    Authors: Li Et al.
    Br J Pharmacol  2013;170:489
  6. Estrogen modulates NFκB signaling by enhancing IκBα levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-β.
    Authors: Xing Et al.
    PLoS One  2012;7:e36890
  7. Src Inhibition with saracatinib reverses fulves. resistance in ER-positive ovarian cancer models in vitro and in vivo.
    Authors: Simpkins Et al.
    Clin Cancer Res  2012;18:5911
  8. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.
    Authors: Guo Et al.
    J Biol Chem  2011;286:27882

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