RS 23597-190 hydrochloride
Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Biological Activity
RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT4 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
RS 23597-190: a potent and selective 5-HT4 receptor antagonist.
Eglen et al.
Br.J.Pharmacol., 1993;110:119 -
Central 5-HT4 receptors.
Eglen et al.
TiPS, 1995;16:391
Product Datasheets
Citations for RS 23597-190 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:
5 Citations: Showing 1 - 5
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Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
Authors: Du Et al.
FASEB J 2015;29:2194
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Neuregulin-1 enhances depolarization-induced GABA release.
Authors: Woo Et al.
Neuron 2007;54:599
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5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala.
Authors: Huang and Kandel
J Pharmacol Exp Ther 2007;27:3111
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Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats.
Authors: Kato Et al.
J Neurosci 2006;26:1787
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Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.
Authors: Xiang Et al.
J Neurophysiol 2005;93:1145
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