RS 79948 hydrochloride
Chemical Name: (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride
Purity: ≥99%
Biological Activity
RS 79948 hydrochloride is a α2-adrenoreceptor antagonist (Kd values are; 0.18, 0.19 and 0.42 nM for α2B α2C and α2A, respectively in rat).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
(8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α2-adrenoceptor antagonist.
Clark et al.
J. Med. Chem., 1989;32:2034 -
Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors.
Hume et al.
Eur.J.Pharmacol., 1996;317:67 -
[3H]RS79948-197 binding to rat, guinea pig and pig α2A-, α2B and α2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine.
Uhlen et al.
Eur.J.Pharmacol., 1998;343:93
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Citations for RS 79948 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 79948 hydrochloride include:
4 Citations: Showing 1 - 4
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Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor.
Authors: Chen Et al.
Cell Reports 2019;29:2936
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Structural Basis of the Diversity of Adrenergic Receptors.
Authors: Qu Et al.
Cell Reports 2019;29:2929
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Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
Authors: Hirono
Neuropharmacology 2017;118:79
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High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
Authors: Zacharia Et al.
PLoS One 2013;8:e65969
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