RX 821002 hydrochloride
Chemical Name: 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
Purity: ≥99%
Biological Activity
RX 821002 hydrochloride is a potent, selective α2-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pericytes impair capillary blood flow and motor function after chronic spinal cord injury
Y Li, AM Lucas-Osma, S Black, MV Bandet, MJ Stephens, R Vavrek, L Sanelli, KK Fenrich, AF Di Narzo, S Dracheva, IR Winship, K Fouad, DJ Bennett
Nat. Med., 2017;0(0):. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines.
Erdbrugger et al.
J.Pharmacol.Exp.Ther., 1995;273:1287 -
Characterisation of [3H]RX 821002 binding to alpha-2 adrenergic receptor subtypes.
O'Rourke et al.
J.Pharmacol.Exp.Ther., 1994;268:1362 -
Antagonists that differentiate between α2A- and α2D-adrenoceptors.
Trendelenburg et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1996;353:245
Product Datasheets
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Citations for RX 821002 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RX 821002 hydrochloride include:
7 Citations: Showing 1 - 7
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An improved yeast surface display platform for the screening of nanobody immune libraries.
Authors: Uchański Et al.
Sci Rep 2019;9:382
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Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome.
Authors: Staedtke Et al.
Nature 2018;564:273
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Pericytes impair capillary blood flow and motor function after chronic spinal cord injury.
Authors: Li Et al.
Nat Med 2017;23:733
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Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.
Authors: Alves Et al.
J Chem Biol 2014;9:e83900
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Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
Authors: Hott Et al.
Br J Pharmacol 2012;167:207
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Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipr. administration.
Authors: Deupree Et al.
BMC Pharmacol 2008;8:17
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Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats.
Authors: Crestani Et al.
Br J Pharmacol 2008;153:583
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