S 18886
Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
Purity: ≥98%
Biological Activity
S 18886 is a potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists.
Cimetière et al.
Bioorg.Med.Chem.Lett., 1998;8:1375 -
Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists.
Wang et al.
ACS Med.Chem.Lett., 2014;5:1015
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for S 18886
There are currently no reviews for this product. Be the first to review S 18886 and earn rewards!
Have you used S 18886?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
