(S)-4-Carboxyphenylglycine
Purity: ≥99%
Biological Activity
(S)-4-Carboxyphenylglycine is a competitive group I metabotropic glutamate receptor antagonist, with selectivity for mGlu1a/1a over mGlu5a/5b.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Yokukansan, a kampo medicine, protects PC12 cells from glutamate-induced death by augmenting gene expression of cystine/glutamate antiporter system Xc-.
Kanno, Hitomi, Kawakami, Zenji, Mizoguchi, Kazushig, Ikarashi, Yasushi, Kase, Yoshio
PLoS ONE, 2014;9(12):e116275. -
Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection
R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar
J. Leukoc. Biol., 2017;0(0):. -
Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses.
Brabet et al.
Neuropharmacology, 1995;34:895 -
Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.
Birse et al.
Neuroscience, 1993;52:481 -
Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine (CPG) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
Eaton et al.
Eur.J.Pharmacol., 1993;244:195 -
Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.
Doherty et al.
Br.J.Pharmacol., 1999;126:205
Product Datasheets
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Citations for (S)-4-Carboxyphenylglycine
The citations listed below are publications that use Tocris products. Selected citations for (S)-4-Carboxyphenylglycine include:
7 Citations: Showing 1 - 7
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Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
Authors: Riz Et al.
Oncotarget 2016;7:66360
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Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport.
Authors: Griffin Et al.
Front Pharmacol 2015;6:27
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Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Authors: Mahler Et al.
J Young Investig 2014;19:49
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Augmented cystine-glutamate exchange by pituitary adenylate cyclase-activating polypeptide signaling via the VPAC1 receptor.
Authors: Resch Et al.
Synapse 2014;
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Cytokine Production Modified by System X(c)- After PM10 and Asbestos Exposure.
Authors: Overocker and Pfau
Proc Natl Acad Sci U S A 2012;23:34
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Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.
Authors: Liu Et al.
Mol Pharmacol 2007;72:1637
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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Authors: Porter Et al.
J Pharmacol Exp Ther 2005;315:711
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