SA 4503 dihydrochloride
Chemical Name: 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride
Purity: ≥98%
Biological Activity
SA 4503 dihydrochloride is a selective σ1 receptor agonist (IC50 = 17.4 nM). Exhibits selectivity for σ1 over σ2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitro and attenuates myocardial hypertrophy in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.
Ruscher et al.
Brain, 2011;134:732 -
Binding properties of SA4503, a novel and selective sigma 1 receptor agonist.
Matsuno et al.
Eur.J.Pharmacol., 1996;306:271 -
Stimulation of s1-receptor restores abnormal mitochondrial Ca2+ mobilization and ATP production following cardiac hypertrophy.
Tagashira et al.
Biochim.Biophys.Acta, 2013;1830:3082 -
σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503.
Lever et al.
Synapse, 2006;59:350
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Citation for SA 4503 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SA 4503 dihydrochloride include:
1 Citation: Showing 1 - 1
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σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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