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Salvinorin B

Catalog #: 5611
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5611/1
Salvinorin B | CAS No. 92545-30-7 | DREADD Activators
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Description: Activator of κ-opioid DREADD (KORD)

Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

Salvinorin B is a potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A.

Technical Data

M.Wt:
390.43
Formula:
C21H26O7
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
92545-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Salvinorin B

The citations listed below are publications that use Tocris products. Selected citations for Salvinorin B include:

4 Citations: Showing 1 - 4

  1. Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function
    Authors: Xiong Et al.
    Cell Stem Cell  2021;28:112
  2. Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction.
    Authors: Yun Ha Et al.
    Biol Psychiatry  2020;88:746-757
  3. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrain-projections from the insular cortex.
    Authors: Pina Et al.
    Neuropharmacology  2020;165:107831
  4. DREADDS: Use and application in behavioral neuroscience.
    Authors: Smith Et al.
    Behav Neurosci  2016;130:137

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