SB 239063

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Sirt1, p53, and p38(MAPK) Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation.
   Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Iseki H, Katano M, Kamon M, Hirasaki M, Nishimoto M, Okazaki Y, Okuda A
   Stem Cells, 2012;30(8):1634-44.
2. Regulation of the CCL2 Gene in Pancreatic beta-Cells by IL-1beta and Glucocorticoids: Role of MKP-1.
   Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, Biggerstaff J, Zhao L, Karlstad M, Collier J
   PLoS ONE, 2012;7(10):e46986.
3. Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue
   T Uchiyama, F Okajima, C Mogi, A Tobo, S Tomono, K Sato
   PLoS ONE, 2017;12(6):e0178769.
4. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.
   Barone et al.
   J.Pharmacol.Exp.Ther., 2001;296:312
5. The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury.
   Legos et al.
   Eur.J.Pharmacol., 2002;447:37
6. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.
   Underwood et al.
   J.Pharmacol.Exp.Ther., 2000;293:281

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