SB 277011A dihydrochloride
Chemical Name: N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride
Purity: ≥98%
Biological Activity
SB 277011A dihydrochloride is a selective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). Brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Pharmacological actions of a novel, high-affinity, and selective human DA D3 receptor antagonist, SB-277011-A.
Reavill et al.
J.Pharmacol.Exp.Ther., 2000;294:1154 -
Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective DA D3 receptor antagonist with high oral bioavailability and CNS pe
Stemp et al.
J.Med.Chem., 2000;43:1878
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Citation for SB 277011A dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SB 277011A dihydrochloride include:
1 Citation: Showing 1 - 1
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Electroacupuncture reduces cocaine-induced seizures and mortality in mice.
Authors: Chen Et al.
Nat Neurosci 2013;2013:134610
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