SB 399885 hydrochloride

Catalog #: 3189
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3189/10
3189/50

SB 399885 hydrochloride | CAS No. 402713-81-9 | 5-HT6 Receptor Antagonists

1 Image

Description: Potent and selective 5-HT6 antagonist

Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride

Purity: ≥99%

View All Products for 5-HT6 Receptor Antagonists

Product Details

Citations (2)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SB 399885 hydrochloride is a potent, brain penetrant, orally active 5-HT₆ antagonist. Displays > 200-fold selectivity for 5-HT₆ over other 5-HT receptors (pK_i values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT₆ receptors respectively).

Technical Data

M.Wt:

482.81

Formula:

C₁₈H₂₁Cl₂N₃O₄S.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

402713-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Effects of the brain-penetrant and selective 5-HT₆ receptor antagonist SB-399885 in animal models of anxiety and depression.
Wesolowska and Nikiforuk
Neuropharmacology, 2007;52:1274
The selective 5-HT₆ receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.
Foley et al.
Neuropharmacology, 2008;54:1166

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SB 399885 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 399885 hydrochloride include:

2 Citations: Showing 1 - 2

Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
Authors: Nagata Et al.
Sci Rep 2019;9:16438
Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia.
Authors: Garfield Et al.
J Exp Med 2014;266:201

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SB 399885 hydrochloride

There are currently no reviews for this product. Be the first to review SB 399885 hydrochloride and earn rewards!

Have you used SB 399885 hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.