SB 590885

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
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   Nature, 2015;522(7555):216-20.
2. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na�ve ESCs
   Y Shan, Z Liang, Q Xing, T Zhang, B Wang, S Tian, W Huang, Y Zhang, J Yao, Y Zhu, K Huang, Y Liu, X Wang, Q Chen, J Zhang, B Shang, S Li, X Shi, B Liao, C Zhang, K Lai, X Zhong, X Shu, J Wang, H Yao, J Chen, D Pei, G Pan
   Nat Commun, 2017;8(1):672.
3. BMI1 enables interspecies chimerism with human pluripotent stem cells
   K Huang, Y Zhu, Y Ma, B Zhao, N Fan, Y Li, H Song, S Chu, Z Ouyang, Q Zhang, Q Xing, C Lai, N Li, T Zhang, J Gu, B Kang, Y Shan, K Lai, W Huang, Y Mai, Q Wang, J Li, A Lin, Y Zhang, X Zhong, B Liao, L Lai, J Chen, D Pei, G Pan
   Nat Commun, 2018;9(1):4649.
4. Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at na�ve state
   Y Wang, C Zhao, Z Hou, Y Yang, Y Bi, H Wang, Y Zhang, S Gao
   Elife, 2018;7(0):.
5. Endophilin marks and controls a clathrin-independent endocytic pathway.
   Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
   Nature, 2015;517(7535):460-5.
6. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
   King et al.
   Cancer Res., 2006;66:11100
7. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
   Takle et al.
   Bioorg.Med.Chem.Lett., 2006;16:378
8. Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
   J Pontis, E Planet, S Offner, P Turelli, J Duc, A Coudray, TW Theunissen, R Jaenisch, D Trono
   Cell Stem Cell, 2019;0(0):.
9. Capturing human trophoblast development with naive pluripotent stem cells in�vitro
   S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima
   Cell Stem Cell, 2021;28(6):1023-1039.e13.

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