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SB 772077B dihydrochloride

Catalog #: 4118
1 Citation Datasheet / COA / SDS
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4118/50
SB 772077B dihydrochloride | CAS No. 607373-46-6 | Rho-kinase Inhibitors
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Description: Potent Rho-kinase inhibitor; vasodilator

Chemical Name: (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC50 value of approximately 5.6 nM at recombinant human ROCK1 and 2). Decreases pulmonary and systemic arterial blood pressures and increases cardiac output. Exhibits vasodilator activity that is more potent than Y-27632 (Cat. No 1254) or Fasudil (Cat. No. 0541).

Technical Data

M.Wt:
415.28
Formula:
C15H18N8O2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
607373-46-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

Background References

  1. Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor.
    Dhaliwal et al.
    J.Pharm.Exp.Ther., 2009;330:334
  2. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.
    Doe et al.
    J.Pharmacol.Exp.Ther., 2007;320:89

Product Datasheets

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Citation for SB 772077B dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SB 772077B dihydrochloride include:

1 Citation: Showing 1 - 1

  1. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
    Authors: Lotz-Jenne Et al.
    Oncotarget  2016;7:25983

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