SC 144 hydrochloride

Catalog #: 4963
7 Citations Datasheet / COA / SDS

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SC 144 hydrochloride | CAS No. 917497-70-2 | Cytokine Compounds

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Description: gp130 inhibitor; blocks cytokine-triggered gp130 signaling

Chemical Name: 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride

Purity: ≥98%

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Product Details

Citations (7)

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Biological Activity

SC 144 hydrochloride is an inhibitor of gp130 (IC₅₀ = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.

Technical Data

M.Wt:

358.76

Formula:

C₁₆H₁₁FN₆O.HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

917497-70-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway
SM Lee, HY Park, YS Suh, EH Yoon, J Kim, WH Jang, WS Lee, SG Park, IW Choi, I Choi, SW Kang, H Yun, T Teshima, B Kwon, SK Seo
Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer.
Xu et al.
Mol.Cancer Ther., 2013;12:937

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Citations for SC 144 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SC 144 hydrochloride include:

7 Citations: Showing 1 - 7

Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior.
Authors: Praachi Et al.
Eneuro 2022;9
A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Authors: Jop Et al.
Development 2022;149
Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour.
Authors: Richard Et al.
Elife 2022;11
Sensory perception drives food avoidance through excitatory basal forebrain circuits.
Authors: Jennifer Et al.
Elife 2019;8
Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF.
Authors: Theo Et al.
Exp Neurol 2019;312:20-32
Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion.
Authors: Juan Et al.
Methods Mol Biol 2019;1919:227-235
Exogenous melatonin protects small-for-size liver grafts by promoting monocyte infiltration and releases interleukin-6.
Authors: Anurag Et al.
J Pineal Res 2018;65:e12486

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