SCH 79797 dihydrochloride

Tocris Bioscience | Catalog # 1592

Potent, selective non-peptide PAR1 antagonist
Tocris Bioscience

Key Product Details

Description

Potent, selective non-peptide PAR1 antagonist
View all Protease-Activated Receptor Antagonists »

Product Description

SCH 79797 dihydrochloride is a potent, selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). Inhibits haTRAP-induced- but not γ-thrombin-, ADP- or collagen-induced human platelet aggregation. Selectively blocks PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in vascular smooth muscle cells. Also broad spectrum antibiotic. Kills bacteria by a dual action of inhibiting dihydrofolate reductase and interfering with bacterial cell membrane integrity.

Product Specifications for SCH 79797 dihydrochloride

Molecular Weight

444.41

Formula

C23H25N5.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

CAS Number

1216720-69-2

PubChem ID

45073452

InChI Key

NNJTXSQXGHYXAJ-UHFFFAOYSA-N

SMILES

Cl.Cl.CC(C)C1=CC=C(CN2C=CC3=C2C=CC2=NC(NC4CC4)=NC(N)=C32)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.22 50
Ethanol 2.22 5

Preparing Stock Solutions for SCH 79797 dihydrochloride

The following data is based on the product molecular weight 444.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.50 mL 22.50 mL 45.00 mL
2.5 mM 0.90 mL 4.50 mL 9.00 mL
5 mM 0.45 mL 2.25 mL 4.50 mL
25 mM 0.09 mL 0.45 mL 0.90 mL

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Product Documents for SCH 79797 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SCH 79797 dihydrochloride

For research use only

Citations for SCH 79797 dihydrochloride

Customer Reviews for SCH 79797 dihydrochloride (1)

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  • Excellent inhibitor
    Name: Anonymous
    Species: Human
    Assay Type: Ex Vivo
    Cell Line/Tissue: Blood plasma
    Verified Customer | Posted 03/18/2021
    The experiment was aimed to test the thrombin activity in the blood plasma of KO mice. SCH 79797 was used at a concentration of 0.1 micro Molar.
    SCH 79797 dihydrochloride 1592

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