Senexin A
Chemical Name: 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride
Purity: ≥98%
Biological Activity
Senexin A is a cyclin-dependent kinase 8 (cdk8) inhibitor (IC50 = 280 nM). Also binds to cdk19 in an ATP-competitive manner. Inhibits p21-induced transcription. Reverses doxorubicin-induced tumor-promoting paracrine activities in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Porter, Donald C, Farmaki, Elena, Altilia, Serena, Schools, Gary P, West, Deborah, Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy, Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence, Papavassiliou, Athanasi, Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S, Gyorffy, Balazs, Wentland, Mark P, Broude, Eugenia, Kiaris, Hippokra, Roninson, Igor B
Proc Natl Acad Sci U S A, 2012-08-06;109(34):13799-804.
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Citations for Senexin A
The citations listed below are publications that use Tocris products. Selected citations for Senexin A include:
5 Citations: Showing 1 - 5
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The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
Authors: Katrina F Et al.
J Biol Chem 2020;295:16280-16291
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Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism.
Authors: Rebecca Et al.
Viruses 2020;12
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CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
Authors: Jing Et al.
Cell Rep 2019;28:2892-2904.e7
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The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming.
Authors: Tang Et al.
Cell Metab 2018;27:1040
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Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.
Authors: Br?gelmann Et al.
Clin Cancer Res 2017;23:1829
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