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Sertraline hydrochloride

Catalog #: 2395
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2395/10
2395/50
Sertraline hydrochloride | CAS No. 79559-97-0 | 5-HT Transporter Inhibitors
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Description: 5-HT reuptake inhibitor

Chemical Name: (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

Sertraline is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) that is an orally active antidepressant. Sertraline also decreases ergosterol biosynthesis and exhibits antifungal activity against Candida auris in vitro. Sertraline acts as an inhibitor of SHMT(serine hydroxymethyltransferase), inhibiting serine/glycine synthesis and proliferation of serine/glycine synthesis-dependent breast cancer cell lines in vitro and in vivo.

Technical Data

M.Wt:
342.69
Formula:
C17H17Cl2N.HCl
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
79559-97-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Sertraline hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Sertraline hydrochloride include:

3 Citations: Showing 1 - 3

  1. Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis
    Authors: Lyons Et al.
    The journal of Neuroscience  2016;36:7392
  2. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
    Authors: Hooper Et al.
    Am J Physiol Heart Circ Physiol  2016;311:H572
  3. Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.
    Authors: Pai Et al.
    J Neurosci  2015;35:4366

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